Polyketide synthase 13-IN-2

• 常用名: Polyketide synthase 13-IN-2
• 英文名: Polyketide synthase 13-IN-2
• CAS号: 2219338-48-2
• 分子量: 379.41
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₂H₂₁NO₅
• 熔点: N/A
• 闪点: N/A

Polyketide synthase 13-IN-2用途

聚酮合酶13-IN-2(comp 42)是一种抗结核分枝杆菌的聚酮合酶13抑制剂,MIC为0.25μg/mL[1]。

Polyketide synthase 13-IN-2名称

• 英文名: Polyketide synthase 13-IN-2

Polyketide synthase 13-IN-2生物活性

• 描述: 聚酮合酶13-IN-2(comp 42)是一种抗结核分枝杆菌的聚酮合酶13抑制剂,MIC为0.25μg/mL[1]。
• 相关类别:
  研究领域 >> 感染
  研究领域 >> 炎症/免疫
  信号通路 >> 抗感染 >> 细菌
• 参考文献:

  [1]. Wei Zhang, et al. Identification of Novel Coumestan Derivatives as Polyketide Synthase 13 Inhibitors against Mycobacterium tuberculosis. J Med Chem. 2018 Feb 8;61(3):791-803.

Polyketide synthase 13-IN-2物理化学性质

• 分子式: C₂₂H₂₁NO₅
• 分子量: 379.41

Polyketide synthase 13-IN-2靶点实验

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实验名称：Selectivity index, ratio of IC50 for African green monkey Vero cells to MIC=<90 for M... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4059069

实验名称：Cytotoxicity against human MRC5 cells after 48 hrs by CellTiter96 AQueous one solutio... 来源：ChEMBL 靶标：MRC5 External Id：CHEMBL4059070

实验名称：Inhibition of PKS13 in Mycobacterium tuberculosis H37Rv assessed as reduction in bact... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4059067

实验名称：Cytotoxicity against African green monkey Vero cells after 72 hrs by MABA 来源：ChEMBL 靶标：Vero External Id：CHEMBL4059068

实验名称：Antitubercular activity against resistant Mycobacterium tuberculosis harboring PKS13 ... 来源：ChEMBL 靶标：Mycobacterium tuberculosis External Id：CHEMBL4059077

实验名称：Selectivity ratio of MIC=<90 for resistant Mycobacterium tuberculosis harboring PKS13... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4059078

实验名称：Metabolic stability in human liver microsomes assessed as parent compound remaining a... 来源：ChEMBL 靶标：Liver External Id：CHEMBL4059076

实验名称：Cytotoxicity against human HEK293 cells after 48 hrs by CellTiter96 AQueous one solut... 来源：ChEMBL 靶标：HEK293 External Id：CHEMBL4059073

实验名称：Antitubercular activity against Mycobacterium tuberculosis H37Rv infected in Balb/C m... 来源：ChEMBL 靶标：Mycobacterium tuberculosis External Id：CHEMBL4059074

实验名称：Cytotoxicity against HFL1 cells after 48 hrs by CellTiter96 AQueous one solution assa... 来源：ChEMBL 靶标：HFL1 External Id：CHEMBL4059071

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