Itepekimab

• 常用名: Itepekimab
• 英文名: Itepekimab
• CAS号: 2226742-52-3
• 分子量: N/A
• 密度: N/A
• 沸点: N/A
• 分子式: N/A
• 熔点: N/A
• 闪点: N/A

Itepekimab用途

Itepekimab(REGN-3500；SAR-440340)是IL-33的单克隆抗体。在先前的临床研究中,Itepekimab可减少气道炎症和相关组织损伤。Itepekimab在哮喘中具有临床活性,在慢性阻塞性肺病(COPD)和儿童特应性皮炎(AD)中具有潜在作用[1][2][3][4]。

Itepekimab名称

• 英文名: Itepekimab

Itepekimab生物活性

• 描述: Itepekimab(REGN-3500；SAR-440340)是IL-33的单克隆抗体。在先前的临床研究中,Itepekimab可减少气道炎症和相关组织损伤。Itepekimab在哮喘中具有临床活性,在慢性阻塞性肺病(COPD)和儿童特应性皮炎(AD)中具有潜在作用[1][2][3][4]。
• 相关类别:
  信号通路 >> 免疫及炎症 >> 白细胞介素相关
  研究领域 >> 炎症/免疫
• 体外研究: Itepekimab公司降低了戒烟者血液中嗜酸性粒细胞数[5]。
• 参考文献:

  [1]. Wechsler ME, et al. Efficacy and Safety of Itepekimab in Patients with Moderate-to-Severe Asthma. N Engl J Med. 2021 Oct 28;385(18):1656-1668.

  [2]. Rabe KF, et al. Safety and efficacy of itepekimab in patients with moderate-to-severe COPD: a genetic association study and randomised, double-blind, phase 2a trial. Lancet Respir Med. 2021 Nov;9(11):1288-1298.

  [3]. Kosloski MP, et al. Pharmacokinetics and pharmacodynamics of itepekimab in healthy adults and patients with asthma: Phase I first-in-human and first-in-patient trials. Clin Transl Sci. 2022 Feb;15(2):384-395.

  [4]. Scott JB, et al. Novel treatments for pediatric atopic dermatitis. Curr Opin Pediatr. 2021 Aug 1;33(4):392-401.

  [5]. Singh D. IL-33 in COPD: the hunt for responder subgroups. Lancet Respir Med. 2022 May;10(5):425-426.

Itepekimab物理化学性质

暂时没有任何物化性质资料