RORγt inverse agonist 23

• 常用名: RORγt inverse agonist 23
• 英文名: RORγt inverse agonist 23
• CAS号: 2230779-18-5
• 分子量: 471.61
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₆H₃₃NO₅S
• 熔点: N/A
• 闪点: N/A

RORγt inverse agonist 23用途

RORγt反向激动剂23是一种有效、选择性、口服的新型视黄酸受体相关孤儿受体γt反向激动剂。

RORγt inverse agonist 23名称

• 英文名: RORγt inverse agonist 23

RORγt inverse agonist 23生物活性

• 描述: RORγt反向激动剂23是一种有效、选择性、口服的新型视黄酸受体相关孤儿受体γt反向激动剂。
• 相关类别:
  信号通路 >> 代谢酶/蛋白酶 >> ROR
  研究领域 >> 炎症/免疫
• 参考文献:

  [1]. Chen L, et al. Discovery of Chromane-6-Sulfonamide Derivative as a Potent, Selective, and Orally Available Novel Retinoic Acid Receptor-Related Orphan Receptor γt Inverse Agonist. J Med Chem. 2021 Nov 11;64(21):16106-16131.

RORγt inverse agonist 23物理化学性质

• 分子式: C₂₆H₃₃NO₅S
• 分子量: 471.61

RORγt inverse agonist 23靶点实验

查看更多实验

实验名称：Inhibition of RORgammat in human Jurkat cells assessed as inhibition of RORgammat tra... 来源：ChEMBL 靶标：Nuclear receptor ROR-gamma External Id：CHEMBL5229001

实验名称：Lipophilicity, log D of the compound at pH 7.4 来源：ChEMBL 靶标：N/A External Id：CHEMBL5229000

实验名称：Metabolic stability in human liver microsomes assessed as half life incubated for 5 t... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5229003

实验名称：Inhibition of RORgammat in human Jurkat cells assessed as inhibition of RORgammat tra... 来源：ChEMBL 靶标：Nuclear receptor ROR-gamma External Id：CHEMBL5229002

实验名称：Displacement of BODIPY from APC-labelled human RORgammat LBD incubated for 15 mins by... 来源：ChEMBL 靶标：Nuclear receptor ROR-gamma External Id：CHEMBL5228999

实验名称：Antiinflammatory activity against imiquimod-induced Balb/c mouse skin inflammation mo... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL5229032

实验名称：Antiinflammatory activity against imiquimod-induced Balb/c mouse skin inflammation mo... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL5229029

实验名称：Antiinflammatory activity against imiquimod-induced Balb/c mouse skin inflammation mo... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL5229028

实验名称：Toxicity in Balb/c mouse assessed as inflammatory cell infiltration at 10 to 20 mg/kg... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5229031

实验名称：Toxicity in Balb/c mouse assessed as body weight loss at 5 to 20 mg/kg, po administer... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5229030

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