Anticancer agent 164

• 常用名: Anticancer agent 164
• 英文名: Anticancer agent 164
• CAS号: 2235393-30-1
• 分子量: 540.58
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₁H₂₃F₃N₈O₂S₂
• 熔点: N/A
• 闪点: N/A

Anticancer agent 164用途

CML-IN-1 (compound 7) 是一种有效的抗癌剂。CML-IN-1对人慢性粒细胞白血病 (CML) 细胞系 K562 表现出非常好的诱导凋亡 (apoptosis) 作用。CML-IN-1 通过显着降低 PI3K/Akt 信号通路的蛋白磷酸化发挥作用。CML-IN-1 (compound 4) 还通过抑制结直肠癌中的 MEK/ERK 信号通路来抑制细胞增殖。

Anticancer agent 164名称

• 英文名: Anticancer agent 164

Anticancer agent 164生物活性

• 描述: CML-IN-1 (compound 7) 是一种有效的抗癌剂。CML-IN-1对人慢性粒细胞白血病 (CML) 细胞系 K562 表现出非常好的诱导凋亡 (apoptosis) 作用。CML-IN-1 通过显着降低 PI3K/Akt 信号通路的蛋白磷酸化发挥作用。CML-IN-1 (compound 4) 还通过抑制结直肠癌中的 MEK/ERK 信号通路来抑制细胞增殖。
• 相关类别:
  信号通路 >> 细胞凋亡 >> 细胞凋亡
  研究领域 >> 癌症
  信号通路 >> MAPK/ERK信号通路 >> MEK
  信号通路 >> PI3K/Akt/mTOR 信号通路 >> PI3K
• 参考文献:

  [1]. Li W, et al. Design and synthesis of novel 1-phenyl-3-(5-(pyrimidin-4-ylthio)-1,3,4-thiadiazol- 2-yl)urea derivatives with potent anti-CML activity throughout PI3K/AKT signaling pathway. Bioorg Med Chem Lett. 2019 Jul 15;29(14):1831-1835.

  [2]. Li W, et al. A novel 4-(1,3,4-thiadiazole-2-ylthio)pyrimidine derivative inhibits cell proliferation by suppressing the MEK/ERK signaling pathway in colorectal cancer. Acta Pharm. 2023 Sep 14;73(3):489-502.

Anticancer agent 164物理化学性质

• 分子式: C₂₁H₂₃F₃N₈O₂S₂
• 分子量: 540.58

Anticancer agent 164靶点实验

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实验名称：Induction of apoptosis in human K562 cells assessed as increase in apoptotic cells at... 来源：ChEMBL 靶标：K562 External Id：CHEMBL4342182

实验名称：Antiproliferative activity against human K562 cells assessed as inhibition of cell vi... 来源：ChEMBL 靶标：K562 External Id：CHEMBL4342181

实验名称：Induction of p53 phosphorylation at S392, S46, S15 residues in human K562 cells up to... 来源：ChEMBL 靶标：Cellular tumor antigen p53 External Id：CHEMBL4342180

实验名称：Inhibition of RAF/MEK/ERK signalling n human K562 cells assessed as reduction in ERK1... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4342191

实验名称：Inhibition of MAPK signalling in human K562 cells assessed as effect on p38 phosphory... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4342190

实验名称：Induction of p27 phosphorylation at T198 residues in human K562 cells up to 10 uM inc... 来源：ChEMBL 靶标：Cyclin-dependent kinase inhibitor 1B External Id：CHEMBL4342189

实验名称：Inhibition of PYK2 phosphorylation in human K562 cells up to 10 uM incubated for 48 h... 来源：ChEMBL 靶标：Protein-tyrosine kinase 2-beta External Id：CHEMBL4342188

实验名称：Inhibition of PI3K/Akt signaling in human K562 cells assessed as reduction in GSK3alp... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4342187

实验名称：Inhibition of PI3K/Akt signaling in human K562 cells assessed as reduction in mTOR ph... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4342186

实验名称：Inhibition of PI3K/Akt signaling in human K562 cells assessed as reduction in p70S6K ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4342185

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