JG-258

• 常用名: JG-258
• 英文名: JG-258
• CAS号: 2241517-83-7
• 分子量: 452.06
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₀H₂₂ClN₃OS₃
• 熔点: N/A
• 闪点: N/A

JG-258用途

JG-258是Hsp70抑制剂的非活性阴性对照[1]。

JG-258名称

• 英文名: JG-258

JG-258生物活性

• 描述: JG-258是Hsp70抑制剂的非活性阴性对照[1]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 代谢酶/蛋白酶 >> HSP
  信号通路 >> 细胞周期/DNA损伤 >> HSP
• 参考文献:

  [1]. Hao Shao, et al. Exploration of Benzothiazole Rhodacyanines as Allosteric Inhibitors of Protein-Protein Interactions with Heat Shock Protein 70 (Hsp70). J Med Chem. 2018 Jul 26;61(14):6163-6177.

JG-258物理化学性质

• 分子式: C₂₀H₂₂ClN₃OS₃
• 分子量: 452.06
• InChIKey: PKMOCFPDFBAKKL-KPJFUTMLSA-M
• SMILES: CCn1c(=Cc2scc[n+]2Cc2ccccc2)sc(=C2SCCN2C)c1=O.[Cl-]

JG-258靶点实验

查看更多实验

实验名称：Antiproliferative activity against MEF cells by MTT assay 来源：ChEMBL 靶标：MEF External Id：CHEMBL4137416

实验名称：Antiproliferative activity against human MCF7 cells by MTT assay 来源：ChEMBL 靶标：MCF7 External Id：CHEMBL4137414

实验名称：Antiproliferative activity against human MDA-MB-231 cells by MTT assay 来源：ChEMBL 靶标：MDA-MB-231 External Id：CHEMBL4137415

实验名称：Induction of heat shock response in human MCF7 cells assessed as increase in HSP90 le... 来源：ChEMBL 靶标：Heat shock protein HSP 90-alpha External Id：CHEMBL4137440

实验名称：Induction of apoptosis in human MCF7 cells assessed as caspase-3/7 activation up to 1... 来源：ChEMBL 靶标：MCF7 External Id：CHEMBL4137441

实验名称：Inhibition of HSP70 in human MCF7 cells assessed as reduction of HuR levels up to 10 ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4137438

实验名称：Induction of heat shock response in human MCF7 cells assessed as increase in HSP72 le... 来源：ChEMBL 靶标：Heat shock 70 kDa protein 1A External Id：CHEMBL4137439

实验名称：Inhibition of HSP70 in human MCF7 cells assessed as reduction of CDK4 levels up to 10... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4137436

实验名称：Inhibition of HSP70 in human MCF7 cells assessed as reduction of IAP1 levels up to 10... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4137437

实验名称：Inhibition of HSP70 in human MCF7 cells assessed as reduction of Raf levels up to 10 ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4137434

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