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苯磷硫胺

苯磷硫胺用途

Benfotiamine是维生素B1的衍生物,有抗氧化活性。

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苯磷硫胺名称

[ CAS 号 ]:
22457-89-2

[ 中文名 ]:
苯磷硫胺

[ 英文名 ]:
Benfotiamine

[中文别名 ]:

S-苯甲酰基硫胺O-单磷酸酯

[英文别名 ]:

berdi
S-benzoylthiamine monophosphate
bietamine
biotamin
betivina
S-Benzoyl-thiamin-monophosphat
EINECS 245-013-4
Benfotiamine
neurostop
S-Benzoylthiamine O-Monophosphate

苯磷硫胺生物活性

[ 描述 ]:

Benfotiamine是维生素B1的衍生物,有抗氧化活性。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

天然产物 >> 生物碱

研究领域 >> 神经疾病

[参考文献]

[1]. Tarallo S, Beltramo E, Berrone E, Porta M. Human pericyte-endothelial cell interactions in co-culture models mimicking the diabetic retinal microvascular environment. Acta Diabetol. 2012 Dec;49 Suppl 1:141-51.

[2]. Engelen L, Stehouwer CD, Schalkwijk CG. Current therapeutic interventions in the glycation pathway:Evidence from clinical studies. Diabetes Obes Metab. 2012 Dec 26.

[3]. Hurt JK, Coleman JL, Fitzpatrick BJ, et al. Prostatic acid phosphatase is required for the antinociceptive effects of thiamine and benfotiamine. PLoS One. 2012;7(10):e48562.

[4]. Hans-Peter Hammes, Xueliang Du, Diane Edelstein, et al. Benfotiamine blocks three major pathways of hyperglycemic damage and prevents experimental diabetic retinopathy. Nature Medicine, 2003, 9, 294 - 299

[5]. Loew D. Pharmacokinetics of thiamine derivatives especially of benfotiamine. International Journal of Clinical Pharmacology and Therapeutics, 1996, 34(2):47-50

[6]. Benfotiamine

[相关活性小分子]

苯磷硫胺物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
745.1±70.0 °C at 760 mmHg

[ 熔点 ]:
165ºC

[ 分子式 ]:
C₁₉H₂₃N₄O₆PS

[ 分子量 ]:
466.448

[ 闪点 ]:
404.4±35.7 °C

[ 精确质量 ]:
466.107605

[ PSA ]:
191.05000

[ LogP ]:
1.81

[ 外观性状 ]:
闪光黑色粉末

[ 蒸汽压 ]:
0.0±2.6 mmHg at 25°C

[ 折射率 ]:
1.645

[ 储存条件 ]:
2-8°C

苯磷硫胺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DH6910000

CHEMICAL NAME :: Benzoic acid, thio-, S-ester with N-((4-amino-2-methyl-5-pyrimidinyl)methyl)-N-(4-hydro xy- 2-mercapto-1-methyl-1-butenyl)formamide dihydrogen phosphate (ester)

CAS REGISTRY NUMBER :: 22457-89-2

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C19-H23-N4-O6-P-S

MOLECULAR WEIGHT :: 466.49

WISWESSER LINE NOTATION :: T6N CNJ B1 DZ E1VMY1&UYSVR&2OPQQO

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 15 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,781,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85IPAE "Modern Pharmaceuticals of Japan, III," Tokyo, Japan Pharmaceutical, Medical and Dental Supply Exporters' Assoc., 1968 Volume(issue)/page/year: -,78,1968

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苯磷硫胺安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
R20/21/22

[ 安全声明 (欧洲) ]:
26-36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
2

[ RTECS号 ]:
DH6910000

苯磷硫胺文献

Benfotiamine, a synthetic S-acyl thiamine derivative, has different mechanisms of action and a different pharmacological profile than lipid-soluble thiamine disulfide derivatives.

BMC Pharmacol. 8 , 10, (2008)

Lipid-soluble thiamine precursors have a much higher bioavailability than genuine thiamine and therefore are more suitable for therapeutic purposes. Benfotiamine (S-benzoylthiamine O-monophosphate), a...

The detrimental effects of acute hyperglycemia on myocardial glucose uptake.

Life Sci. 105(1-2) , 31-42, (2014)

Although acute hyperglycemic (AHG) episodes are linked to lower glucose uptake, underlying mechanisms remain unclear. We hypothesized that AHG triggers reactive oxygen species (ROS) production and inc...

The effect of benfotiamine on mu-opioid receptor mediated antinociception in experimental diabetes.

Exp. Clin. Endocrinol. Diabetes 122(3) , 173-8, (2014)

Diabetic neuropathy is a prevalent, disabling disorder. Currently, the only treatments available to patients with diabetic neuropathy are glucose control and pain management. B vitamin present neuropr...

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