伐地那非

• 常用名: 伐地那非
• 英文名: Vardenafil
• CAS号: 224785-90-4
• 分子量: 488.60
• 密度: 1.4±0.1 g/cm3
• 沸点: 692.2ºC at 760mmHg
• 分子式: C₂₃H₃₂N₆O₄S
• 熔点: 214-216ºC
• 闪点: 372.5ºC
• 符号: GHS02, GHS07
• 信号词: Danger

伐地那非用途

Vardenafil是PDE5抑制剂,可作用于勃起功能障碍。

伐地那非作用

起效时间快，15至30分钟之内见效。副作用小，但因个体的差异，仍有不足2%的人会略感轻微头痛。溶于水和乙醇的特性，是目前做壮阳酒类、软胶囊及口服液的理想原料，持续时间可达6小时以上。

伐地那非名称

• 中文名: 盐酸瓦地那非三水合物
• 英文名: vardenafil
• 中文别名: 伐地那非 | 2-[2-乙氧基-5-(4-乙基-哌嗪-1-磺酰基)苯基]-5-甲基-7-丙基-3H-咪唑[5,1-f]-[1,2,4]三联氮-4-酮单盐酸盐三水合物 | 伐地那非三水合盐酸盐 | 盐酸伐地那非

伐地那非生物活性

• 描述: Vardenafil是PDE5抑制剂,可作用于勃起功能障碍。
• 相关类别:
  信号通路 >> 代谢酶/蛋白酶 >> 磷酸二酯酶(PDE)
  研究领域 >> 内分泌
• 参考文献:

  [1]. Saenz de Tejada, I., et al., The phosphodiesterase inhibitory selectivity and the in vitro and in vivo potency of the new PDE5 inhibitor vardenafil. Int J Impot Res, 2001. 13(5): p. 282-90.

  [2]. Goldstein, I., et al., Vardenafil, a new phosphodiesterase type 5 inhibitor, in the treatment of erectile dysfunction in men with diabetes: a multicenter double-blind placebo-controlled fixed-dose study. Diabetes Care, 2003. 26(3): p. 777-83.

伐地那非物理化学性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 692.2ºC at 760mmHg
• 熔点: 214-216ºC
• 分子式: C₂₃H₃₂N₆O₄S
• 分子量: 488.60
• 闪点: 372.5ºC
• PSA: 121.28000
• LogP: 2.65
• InChIKey: SECKRCOLJRRGGV-UHFFFAOYSA-N
• SMILES: CCCc1nc(C)c2c(=O)[nH]c(-c3cc(S(=O)(=O)N4CCN(CC)CC4)ccc3OCC)nn12
• 外观性状: 白色结晶粉末
• 蒸汽压: 5.17E-19mmHg at 25°C
• 折射率: 1.656
• 储存条件: ?20°C

伐地那非安全信息

• 符号: GHS02, GHS07
• 信号词: Danger
• 危害声明: H225-H302 + H312 + H332-H319
• 警示性声明: P210-P261-P302 + P352 + P312-P304 + P340 + P312-P337 + P313-P403 + P235
• 危害码 (欧洲): F,Xn
• 风险声明 (欧洲): 11-20/21/22-36
• 安全声明 (欧洲): 16-36/37
• 危险品运输编码: UN1230 - class 3 - PG 2 - Methanol, solution

伐地那非靶点实验

查看更多实验

实验名称：Primary qHTS assay for inhibitors of alpha-synuclein gene (SNCA) expression 来源：NCGC External Id：SNCA-p-activity-luciferase

实验名称：Octanol-water partition coefficient, log P of the compound 来源：ChEMBL 靶标：N/A External Id：CHEMBL968867

实验名称：Inhibition of PDE5 来源：ChEMBL 靶标：cGMP-specific 3',5'-cyclic phosphodiesterase External Id：CHEMBL968866

实验名称：Selectivity ratio of Ki for PDE6 (unknown origin) to Ki for PDE5 (unknown origin) 来源：ChEMBL 靶标：N/A External Id：CHEMBL4268473

实验名称：Inhibition of PDE5 (unknown origin) 来源：ChEMBL 靶标：cGMP-specific 3',5'-cyclic phosphodiesterase External Id：CHEMBL4268472

实验名称：Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against th... 来源：NCGC 靶标：N/A External Id：s-my-keats_OPM1-m4-1

实验名称：Antiproliferative activity against human PC3 cells at 1 uM after 120 hrs by MTT assay... 来源：ChEMBL 靶标：PC-3 External Id：CHEMBL1226561

实验名称：Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against th... 来源：NCGC 靶标：N/A External Id：s-my-OC1MY5-m4-1

实验名称：Increase the activity of the Burkholderia fixLJ 2-component system 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：Burkholderia multivorans External Id：HMS1625

实验名称：Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against th... 来源：NCGC 靶标：N/A External Id：s-my-KMS_34-m4-1

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伐地那非英文别名

• Vardenafil (INN)
• Vivanza
• 2-{2-Ethoxy-5-[(4-ethylpiperazin-1-yl)sulfonyl]phenyl}-5-methyl-7-propylimidazo[5,1-f][1,2,4]triazin-4(1H)-one
• 4-[2-ethoxy-5-(4-ethyl-piperazine-1-sulfonyl)-phenyl]-9-methyl-7-propyl-3,5,6,8-tetrazabicyclo[4.3.0]nona-3,7,9-trien-2-one
• Vardenafil hydrochloride trihydrate
• [14C]-Vardenafil
• 2-{2-Ethoxy-5-[(4-ethyl-1-piperazinyl)sulfonyl]phenyl}-5-methyl-7-propylimidazo[5,1-f][1,2,4]triazin-4(1H)-one
• 2-[2-ethoxy-5-(4-ethylpiperazin-1-yl)sulfonylphenyl]-5-methyl-7-propyl-1H-imidazo[5,1-f][1,2,4]triazin-4-one
• Vardenafil HCl Trihydrate
• 4-[2-eyhoxy-5-(4-ethylpiperazin-1-yl)sulfonyl-phenyl]-9-methyl-7-propyl-3,5,6,8-tetrazabicyclo[4,3,0] none 3,7,9 trien-2-one
• vardenafil
• Levitra (TN)