瓦地那非盐酸盐

• 常用名: 瓦地那非盐酸盐
• 英文名: Vardenafil
• CAS号: 224785-91-5
• 分子量: 525.064
• 密度: N/A
• 沸点: 692.2ºC at 760 mmHg
• 分子式: C₂₃H₃₃ClN₆O₄S
• 熔点: 214-216ºC
• 闪点: 372.5ºC

瓦地那非盐酸盐用途

Vardenafil盐酸盐是PDE5抑制剂。

瓦地那非盐酸盐名称

• 中文名: 瓦地拉非盐酸盐
• 英文名: Vardenafil hydrochloride
• 中文别名: 2-[2-乙氧基-5-(4-乙基哌嗪-1-基)磺酰苯基]-5-甲基-7-丙基-1H-咪唑并[5,1-f][1,2,4]三嗪-4-酮盐酸盐 | VARDENAFIL盐酸盐 | 伐地那非 | 伐他那非盐酸盐

瓦地那非盐酸盐生物活性

• 描述: Vardenafil盐酸盐是PDE5抑制剂。
• 相关类别:
  信号通路 >> 代谢酶/蛋白酶 >> 磷酸二酯酶(PDE)
  研究领域 >> 心血管疾病
• 参考文献:

  [1]. Saenz de Tejada, I., et al., The phosphodiesterase inhibitory selectivity and the in vitro and in vivo potency of the new PDE5 inhibitor vardenafil. Int J Impot Res, 2001. 13(5): p. 282-90.

  [2]. Goldstein, I., et al., Vardenafil, a new phosphodiesterase type 5 inhibitor, in the treatment of erectile dysfunction in men with diabetes: a multicenter double-blind placebo-controlled fixed-dose study. Diabetes Care, 2003. 26(3): p. 777-83.

瓦地那非盐酸盐物理化学性质

• 沸点: 692.2ºC at 760 mmHg
• 熔点: 214-216ºC
• 分子式: C₂₃H₃₃ClN₆O₄S
• 分子量: 525.064
• 闪点: 372.5ºC
• 精确质量: 524.197266
• PSA: 121.28000
• LogP: 3.82900
• InChIKey: XCMULUAPJXCOHI-UHFFFAOYSA-N
• SMILES: CCCc1nc(C)c2c(=O)[nH]c(-c3cc(S(=O)(=O)N4CCN(CC)CC4)ccc3OCC)nn12.Cl
• 外观性状: 白色至灰白色水晶般的固体
• 蒸汽压: 5.17E-19mmHg at 25°C
• 储存条件: 室温，干燥

瓦地那非盐酸盐靶点实验

查看更多实验

实验名称：In vivo minimal effective dose for inhibition of phosphodiesterase in conscious rabbi... 来源：ChEMBL 靶标：Oryctolagus cuniculus External Id：CHEMBL774888

实验名称：Mean steady-state volume of distribution (Vss) for Vardenafil following oral doses of... 来源：ChEMBL 靶标：Homo sapiens External Id：CHEMBL3889385

实验名称：ERK5 transcriptional activity HTS 来源：24565 靶标：N/A External Id：ERK5 transcriptional activity-HTS

实验名称：Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VER... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4513082

实验名称：NCI human tumor cell line growth inhibition assay. Data for the MCF7 Non-Small Cell L... 来源：DTP/NCI 靶标：N/A External Id：MCF7_OneDose

实验名称：NCI human tumor cell line growth inhibition assay. Data for the IGROV1 Non-Small Cell... 来源：DTP/NCI 靶标：N/A External Id：IGROV1_OneDose

实验名称：Primary high throughput screening by co-culture imaging for identification hits as a ... 来源：23209 靶标：N/A External Id：UIHTS20180925

实验名称：Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Cac... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4303805

实验名称：Evaluation of pharmacokinetic parameters for Vardenafil evaluated following single or... 来源：ChEMBL 靶标：Homo sapiens External Id：CHEMBL3889384

实验名称：Spectrum HTS for Inhibitors of Aerobactin Synthetase IucA 来源：23265 靶标：IucA Synthetase from hypervirulent Klebsiella pneumoniae hvKP1 External Id：IucA Pilot Assay Spectrum Library

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瓦地那非盐酸盐英文别名

• VARDENAFIL,HYDROCHLORIDE SALT
• Nuviva
• Vivanza
• Vardenafil HCl
• Vardenafil (hydrochloride)
• Levitra,Valdenafil
• 1-((3-(1,4-Dihydro-5-methyl-4-oxo-7-propylimidazo[5,1-f][1,2,4]triazin-2-yl)-4-ethoxyphenyl)sulfonyl)-4-ethylpiperazine Hydrochloride
• 2-{2-Ethoxy-5-[(4-ethylpiperazin-1-yl)sulfonyl]phenyl}-5-methyl-7-propylimidazo[5,1-f][1,2,4]triazin-4(1H)-onhydrochlorid
• 2-{2-Ethoxy-5-[(4-ethyl-1-piperazinyl)sulfonyl]phenyl}-5-methyl-7-propylimidazo[5,1-f][1,2,4]triazin-4(1H)-one hydrochloride (1:1)
• Imidazo[5,1-f][1,2,4]triazin-4(1H)-one, 2-[2-ethoxy-5-[(4-ethyl-1-piperazinyl)sulfonyl]phenyl]-5-methyl-7-propyl-, hydrochloride (1:1)
• piperazine, 1-[[3-(1,4-dihydro-5-methyl-4-oxo-7-propylimidazo[5,1-f][1,2,4]triazin-2-yl)-4-ethoxyphenyl]sulfonyl]-4-ethyl-, monohydrochloride
• VARDENAFIL
• VARDENAFILMONOHYDROCHLORIDE(SUBJECTTOPATENTFREE)
• Levitra
• 4-{[4-ethoxy-3-(4-hydroxy-5-methyl-7-propylimidazo[5,1-f][1,2,4]triazin-2-yl)phenyl]sulfonyl}-1-ethylpiperazin-1-ium chloride
• Levitra,Valdenafil.HCl
• 2-{2-ethoxy-5-[(4-ethylpiperazin-1-yl)sulfonyl]phenyl}-5-methyl-7-propylimidazo[5,1-f][1,2,4]triazin-4(1H)-one hydrochloride
• Vardenafil hydrochloride
• 2-{2-éthoxy-5-[(4-éthylpipérazin-1-yl)sulfonyl]phényl}-5-méthyl-7-propylimidazo[5,1-f][1,2,4]triazin-4(1H)-one chlorhydrate