Vardenafil
Modify Date: 2024-01-02 16:53:08
Vardenafil structure
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Common Name | Vardenafil | ||
|---|---|---|---|---|
| CAS Number | 224785-91-5 | Molecular Weight | 525.064 | |
| Density | N/A | Boiling Point | 692.2ºC at 760 mmHg | |
| Molecular Formula | C23H33ClN6O4S | Melting Point | 214-216ºC | |
| MSDS | N/A | Flash Point | 372.5ºC | |
Use of VardenafilVardenafil Hcl is a PDE5 inhibitor used for treating erectile dysfunction.Target: PDE5Vardenafil specifically inhibited the hydrolysis of cGMP by PDE5 with an IC50 of 0.7 nM (6.6 nM). In contrast, the IC50 of vardenafil for PDE1 was 180 nM; for PDE6, 11 nM; for PDE2, PDE3 and PDE4, more than 1000 nM. Relative to PDE5, the ratios of the IC50 for PDE1 were 257 (60), for PDE6 16 (7.4). Vardenafil significantly enhanced the SNP-induced relaxation of human trabecular smooth muscle at 3 nM (10 nM). Vardenafil also significantly potentiated both ACh-induced and transmural electrical stimulation-induced relaxation of trabecular smooth muscle [1]. Both vardenafil doses(10 mg or 20 mg) significantly enhanced the |
| Name | Vardenafil hydrochloride |
|---|---|
| Synonym | More Synonyms |
| Description | Vardenafil Hcl is a PDE5 inhibitor used for treating erectile dysfunction.Target: PDE5Vardenafil specifically inhibited the hydrolysis of cGMP by PDE5 with an IC50 of 0.7 nM (6.6 nM). In contrast, the IC50 of vardenafil for PDE1 was 180 nM; for PDE6, 11 nM; for PDE2, PDE3 and PDE4, more than 1000 nM. Relative to PDE5, the ratios of the IC50 for PDE1 were 257 (60), for PDE6 16 (7.4). Vardenafil significantly enhanced the SNP-induced relaxation of human trabecular smooth muscle at 3 nM (10 nM). Vardenafil also significantly potentiated both ACh-induced and transmural electrical stimulation-induced relaxation of trabecular smooth muscle [1]. Both vardenafil doses(10 mg or 20 mg) significantly enhanced the |
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| Related Catalog | |
| References |
| Boiling Point | 692.2ºC at 760 mmHg |
|---|---|
| Melting Point | 214-216ºC |
| Molecular Formula | C23H33ClN6O4S |
| Molecular Weight | 525.064 |
| Flash Point | 372.5ºC |
| Exact Mass | 524.197266 |
| PSA | 121.28000 |
| LogP | 3.82900 |
| Vapour Pressure | 5.17E-19mmHg at 25°C |
| VARDENAFIL,HYDROCHLORIDE SALT |
| Nuviva |
| Vivanza |
| Vardenafil HCl |
| Vardenafil (hydrochloride) |
| Levitra,Valdenafil |
| 1-((3-(1,4-Dihydro-5-methyl-4-oxo-7-propylimidazo[5,1-f][1,2,4]triazin-2-yl)-4-ethoxyphenyl)sulfonyl)-4-ethylpiperazine Hydrochloride |
| 2-{2-Ethoxy-5-[(4-ethylpiperazin-1-yl)sulfonyl]phenyl}-5-methyl-7-propylimidazo[5,1-f][1,2,4]triazin-4(1H)-onhydrochlorid |
| 2-{2-Ethoxy-5-[(4-ethyl-1-piperazinyl)sulfonyl]phenyl}-5-methyl-7-propylimidazo[5,1-f][1,2,4]triazin-4(1H)-one hydrochloride (1:1) |
| Imidazo[5,1-f][1,2,4]triazin-4(1H)-one, 2-[2-ethoxy-5-[(4-ethyl-1-piperazinyl)sulfonyl]phenyl]-5-methyl-7-propyl-, hydrochloride (1:1) |
| piperazine, 1-[[3-(1,4-dihydro-5-methyl-4-oxo-7-propylimidazo[5,1-f][1,2,4]triazin-2-yl)-4-ethoxyphenyl]sulfonyl]-4-ethyl-, monohydrochloride |
| VARDENAFIL |
| VARDENAFILMONOHYDROCHLORIDE(SUBJECTTOPATENTFREE) |
| Levitra |
| 4-{[4-ethoxy-3-(4-hydroxy-5-methyl-7-propylimidazo[5,1-f][1,2,4]triazin-2-yl)phenyl]sulfonyl}-1-ethylpiperazin-1-ium chloride |
| Levitra,Valdenafil.HCl |
| 2-{2-ethoxy-5-[(4-ethylpiperazin-1-yl)sulfonyl]phenyl}-5-methyl-7-propylimidazo[5,1-f][1,2,4]triazin-4(1H)-one hydrochloride |
| Vardenafil hydrochloride |
| 2-{2-éthoxy-5-[(4-éthylpipérazin-1-yl)sulfonyl]phényl}-5-méthyl-7-propylimidazo[5,1-f][1,2,4]triazin-4(1H)-one chlorhydrate |