SHIP2-IN-1

• 常用名: SHIP2-IN-1
• 英文名: SHIP2-IN-1
• CAS号: 2252247-80-4
• 分子量: 379.22
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₇H₁₃Cl₂FN₄O
• 熔点: N/A
• 闪点: N/A

SHIP2-IN-1用途

SHIP2-IN-1 是一种有效的 SHIP2 抑制剂,IC50 值为 2 µM。SHIP2-IN-1 可使 GSK3β 的 Ser9 位点磷酸化,抑制 GSK3β 的活化。SHIP2-IN-1 可用于阿尔滋海默症的研究。

SHIP2-IN-1名称

• 中文名: SHIP2-IN-1
• 英文名: SHIP2-IN-1

SHIP2-IN-1生物活性

• 描述: SHIP2-IN-1 是一种有效的 SHIP2 抑制剂,IC50 值为 2 µM。SHIP2-IN-1 可使 GSK3β 的 Ser9 位点磷酸化,抑制 GSK3β 的活化。SHIP2-IN-1 可用于阿尔滋海默症的研究。
• 相关类别:
  信号通路 >> 代谢酶/蛋白酶 >> 磷酸酶
  研究领域 >> 神经疾病
• 靶点实验:

  IC50: 2 µM (SHIP2)[1]

• 体外研究: SHIP2-IN-1(化合物43;10μM)显着抑制HT22细胞中PI(3,4)P2的产生[1]。
• 参考文献:

  [1]. Lim JW, et al. Identification of crizotinib derivatives as potent SHIP2 inhibitors for the treatment of Alzheimer's disease. Eur J Med Chem. 2018 Sep 5;157:405-422.

SHIP2-IN-1物理化学性质

• 分子式: C₁₇H₁₃Cl₂FN₄O
• 分子量: 379.22
• InChIKey: ATPYDXUUBCDYKQ-SECBINFHSA-N
• SMILES: CC(Oc1cncc(-c2cnc(N)nc2)c1)c1c(Cl)ccc(F)c1Cl
• 储存条件: -20°C

SHIP2-IN-1靶点实验

查看更多实验

实验名称：Metabolic stability in mouse liver microsomes assessed as parent compound remaining a... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4274866

实验名称：Metabolic stability in rat liver microsomes assessed as parent compound remaining at ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4274865

实验名称：Inhibition of SHIP2 in mouse HT22 cells assessed as decrease in PI(3,4)P2 production ... 来源：ChEMBL 靶标：Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 External Id：CHEMBL4274868

实验名称：Cytotoxicity against mouse HT22 cells assessed as decrease in cell viability at 10 uM... 来源：ChEMBL 靶标：HT-22 External Id：CHEMBL4274867

实验名称：Inhibition of recombinant human CYP3A4 assessed as remaining enzyme activity at 10 uM... 来源：ChEMBL 靶标：Cytochrome P450 3A4 External Id：CHEMBL4274862

实验名称：Inhibition of recombinant human CYP2D6 assessed as remaining enzyme activity at 10 uM... 来源：ChEMBL 靶标：Cytochrome P450 2D6 External Id：CHEMBL4274861

实验名称：Metabolic stability in dog liver microsomes assessed as parent compound remaining at ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4274864

实验名称：Metabolic stability in human liver microsomes assessed as parent compound remaining a... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4274863

实验名称：AUC (0 to t) in Sprague-Dawley rat at 2 mg/kg, iv administered as single dose by LC-M... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL4274874

实验名称：MRT (0 to t) in Sprague-Dawley rat at 2 mg/kg, iv administered as single dose by LC-M... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL4274876

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