DDO-7263

• 常用名: DDO-7263
• 英文名: DDO-7263
• CAS号: 2254004-96-9
• 分子量: 273.24
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₄H₉F₂N₃O
• 熔点: N/A
• 闪点: N/A

DDO-7263用途

DDO-7263是一种1,2,4-恶二唑衍生物,是一种有效的Nrf2激活剂。DDO-7263通过与Rpn6结合来上调Nrf2,从而阻止26S蛋白酶体的组装和泛素化Nrf2的后续降解。DDO-7263激活Nrf2 ARE信号通路并发挥抗炎活性[1]。

DDO-7263名称

• 英文名: DDO-7263

DDO-7263生物活性

• 描述: DDO-7263是一种1,2,4-恶二唑衍生物,是一种有效的Nrf2激活剂。DDO-7263通过与Rpn6结合来上调Nrf2,从而阻止26S蛋白酶体的组装和泛素化Nrf2的后续降解。DDO-7263激活Nrf2 ARE信号通路并发挥抗炎活性[1]。
• 相关类别:
  信号通路 >> NF-κB信号通路 >> KEAP1-Nrf2
  研究领域 >> 炎症/免疫
• 参考文献:

  [1]. Zhen Dai, et al. Target Fishing Reveals a Novel Mechanism of 1,2,4-Oxadiazole Derivatives Targeting Rpn6, a Subunit of 26S Proteasome. J Med Chem. 2022 Mar 24;65(6):5029-5043.

DDO-7263物理化学性质

• 分子式: C₁₄H₉F₂N₃O
• 分子量: 273.24
• InChIKey: HITVBBDLWZDVIV-UHFFFAOYSA-N
• SMILES: Cc1ccc(-c2noc(-c3ccc(F)c(F)c3)n2)cn1

DDO-7263靶点实验

查看更多实验

实验名称：Activation of Nrf2 in human HepG2-ARE-C8 cells assessed as induction of ARE-mediated ... 来源：ChEMBL 靶标：Nuclear factor erythroid 2-related factor 2 External Id：CHEMBL4267379

实验名称：Activation of Nrf2 in human HepG2-ARE-C8 cells assessed as induction of ARE-mediated ... 来源：ChEMBL 靶标：Nuclear factor erythroid 2-related factor 2 External Id：CHEMBL4267378

实验名称：Activation of Nrf2 in human HepG2-ARE-C8 cells assessed as induction of ARE-mediated ... 来源：ChEMBL 靶标：Nuclear factor erythroid 2-related factor 2 External Id：CHEMBL4267381

实验名称：Activation of Nrf2 in human HepG2-ARE-C8 cells assessed as induction of ARE-mediated ... 来源：ChEMBL 靶标：Nuclear factor erythroid 2-related factor 2 External Id：CHEMBL4267380

实验名称：Cytotoxicity against human HepG2 cells at 80 uM after 24 hrs by MTT assay 来源：ChEMBL 靶标：HepG2 External Id：CHEMBL4267377

实验名称：Activation of Nrf2 in human HepG2-ARE-C8 cells assessed as induction of ARE-mediated ... 来源：ChEMBL 靶标：Nuclear factor erythroid 2-related factor 2 External Id：CHEMBL4267376

实验名称：Activation of Nrf2 in human LO2 cells expressing ARE assessed as increase in HO-1 pro... 来源：ChEMBL 靶标：Nuclear factor erythroid 2-related factor 2 External Id：CHEMBL4267389

实验名称：Activation of Nrf2 in human LO2 cells expressing ARE assessed as increase in NQO1 pro... 来源：ChEMBL 靶标：Nuclear factor erythroid 2-related factor 2 External Id：CHEMBL4267388

实验名称：Cytotoxicity against human LO2 cells up to 160 uM after 24 hrs by MTT assay 来源：ChEMBL 靶标：L02 External Id：CHEMBL4267383

实验名称：Activation of Nrf2 in human HepG2-ARE-C8 cells assessed as induction of ARE-mediated ... 来源：ChEMBL 靶标：Nuclear factor erythroid 2-related factor 2 External Id：CHEMBL4267382

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