UAMC-3203盐酸盐

• 常用名: UAMC-3203盐酸盐
• 英文名: UAMC-3203 hydrochloride
• CAS号: 2271358-65-5
• 分子量: 508.12
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₅H₃₈ClN₅O₂S
• 熔点: N/A
• 闪点: N/A

UAMC-3203盐酸盐用途

UAMC-3203 hydrochloride 是有效,选择性的 Ferroptosis 抑制剂,IC50 为 12 nM。

UAMC-3203盐酸盐名称

• 中文名: UAMC-3203盐酸盐
• 英文名: UAMC-3203 hydrochloride

UAMC-3203盐酸盐生物活性

• 描述: UAMC-3203 hydrochloride 是有效,选择性的 Ferroptosis 抑制剂,IC50 为 12 nM。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 细胞凋亡 >> Ferroptosis
  研究领域 >> 代谢疾病
  研究领域 >> 神经疾病
• 靶点实验:

  IC50: 12 nM (Ferroptosis)[1]

• 参考文献:

  [1]. Devisscher L, et al. Discovery of Novel, Drug-Like Ferroptosis Inhibitors with in Vivo Efficacy. J Med Chem. 2018 Nov 21;61(22):10126-10140.

UAMC-3203盐酸盐物理化学性质

• 分子式: C₂₅H₃₈ClN₅O₂S
• 分子量: 508.12
• InChIKey: WBZHHIZXEXJBSM-UHFFFAOYSA-N
• SMILES: Cl.O=S(=O)(NCCN1CCNCC1)c1ccc(NC2CCCCC2)c(NCc2ccccc2)c1
• 储存条件: 2-8℃

UAMC-3203盐酸盐靶点实验

查看更多实验

实验名称：Toxicity in wild type mouse assessed as relative gain in body weight at 20 umol/kg, i... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL4158903

实验名称：Plasma concentration in Wistar rat at 5 mg/kg, iv after 0.083 to 24 hrs by UPLC-MS an... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4158891

实验名称：Drug uptake in Wistar rat liver at 5 mg/kg, iv after 24 hrs by LC-MS analysis 来源：ChEMBL 靶标：N/A External Id：CHEMBL4158892

实验名称：Drug uptake in Wistar rat kidney at 5 mg/kg, iv after 24 hrs by LC-MS analysis 来源：ChEMBL 靶标：N/A External Id：CHEMBL4158893

实验名称：Drug uptake in Wistar rat lung at 5 mg/kg, iv after 24 hrs by LC-MS analysis 来源：ChEMBL 靶标：N/A External Id：CHEMBL4158894

实验名称：Intrinsic clearance in rat liver microsomes at 50 uM after 15 mins to 24 hrs by LC/MS... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4158887

实验名称：Intrinsic clearance in mouse liver microsomes at 50 uM after 15 mins to 24 hrs by LC/... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4158888

实验名称：Inhibition of ferrous ammonium sulphate-induced ferroptosis in human IMR32 cells prei... 来源：ChEMBL 靶标：IMR-32 External Id：CHEMBL4158889

实验名称：In vivo inhibition of iron sulphate-induced ferroptosis in C57BL/6N mouse assessed as... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL4158890

实验名称：Toxicity in wild type mouse assessed as creatinine levels in plasma at 20 umol/kg, ip... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL4158899

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