H-γ-D-Glu-Trp-OH

• 常用名: H-γ-D-Glu-Trp-OH
• 英文名: H-D-Glu(Trp-OH)-OH
• CAS号: 229305-39-9
• 分子量: 333.33900
• 密度: 1.428g/cm3
• 沸点: 737.3ºC at 760 mmHg
• 分子式: C₁₆H₁₉N₃O₅
• 熔点: N/A
• 闪点: 399.7ºC

H-γ-D-Glu-Trp-OH用途

Golotimod (SCV-07),一种具有抗菌活性的免疫调节肽,可显着提高抗结核治疗的功效,刺激胸腺和脾细胞增殖,并改善巨噬细胞功能。Golotimod (SCV-07) 抑制 STAT3 信号传导并调节接受放疗或放疗与顺铂联合用药的动物模型中口腔粘膜炎的持续时间和严重程度。Golotimod (SCV-07) 是复发性生殖器单纯疱疹病毒 2 型 (HSV-2) 的潜在治疗药物。

H-γ-D-Glu-Trp-OH名称

• 中文名: H-γ-D-Glu-Trp-OH
• 英文名: (2R)-2-amino-5-[[(1S)-1-carboxy-2-(1H-indol-3-yl)ethyl]amino]-5-oxopentanoic acid

H-γ-D-Glu-Trp-OH生物活性

• 描述: Golotimod (SCV-07),一种具有抗菌活性的免疫调节肽,可显着提高抗结核治疗的功效,刺激胸腺和脾细胞增殖,并改善巨噬细胞功能。Golotimod (SCV-07) 抑制 STAT3 信号传导并调节接受放疗或放疗与顺铂联合用药的动物模型中口腔粘膜炎的持续时间和严重程度。Golotimod (SCV-07) 是复发性生殖器单纯疱疹病毒 2 型 (HSV-2) 的潜在治疗药物。
• 相关类别:
  信号通路 >> 干细胞及 Wnt 通路 >> STAT
  信号通路 >> 抗感染 >> HSV
  研究领域 >> 感染
  信号通路 >> JAK/STAT信号通路 >> STAT
  研究领域 >> 炎症/免疫
  信号通路 >> 抗感染 >> 细菌
• 靶点实验:

  STAT3[1]

• 参考文献:

  [1]. Rose WA 2nd, et al. An immunomodulating dipeptide, SCV-07, is a potential therapeutic for recurrent genital herpes simplex virus type 2 (HSV-2). Int J Antimicrob Agents. 2008 Sep;32(3):262-6.

  [2]. Geiger JL, et al. The STAT3 pathway as a therapeutic target in head and neck cancer: Barriers and innovations. Oral Oncol. 2016 May;56:84-92.

  [3]. Watkins B, et al. Attenuation of radiation- and chemoradiation-induced mucositis using gamma-D-glutamyl-L-tryptophan (SCV-07). Oral Dis. 2010 Oct;16(7):655-60.

H-γ-D-Glu-Trp-OH物理化学性质

• 密度: 1.428g/cm3
• 沸点: 737.3ºC at 760 mmHg
• 分子式: C₁₆H₁₉N₃O₅
• 分子量: 333.33900
• 闪点: 399.7ºC
• 精确质量: 333.13200
• PSA: 145.51000
• LogP: 1.56310
• InChIKey: CATMPQFFVNKDEY-YPMHNXCESA-N
• SMILES: NC(CCC(=O)NC(Cc1c[nH]c2ccccc12)C(=O)O)C(=O)O
• 蒸汽压: 7.99E-23mmHg at 25°C
• 折射率: 1.659
• 储存条件: -20°C，密闭，干燥

H-γ-D-Glu-Trp-OH靶点实验

查看更多实验

实验名称：Cytotoxicity against HEK293 cells (CO-ADD:MA_007); CC50 by cell viability assay in DM... 来源：ChEMBL 靶标：HEK293 External Id：CHEMBL4296191

实验名称：Antibacterial activity against Acinetobacter baumannii ATCC 19606 (CO-ADD:GN_034); MI... 来源：ChEMBL 靶标：Acinetobacter baumannii External Id：CHEMBL4296188

实验名称：Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 (CO-ADD:GN_042); MIC... 来源：ChEMBL 靶标：Pseudomonas aeruginosa External Id：CHEMBL4296187

实验名称：Antifungal activity against Cryptococcus neoformans H99 ATCC 208821 (CO-ADD:FG_002); ... 来源：ChEMBL 靶标：Cryptococcus neoformans External Id：CHEMBL4296190

实验名称：Antifungal activity against Candida albicans ATCC 90028 (CO-ADD:FG_001); MIC in YNB m... 来源：ChEMBL 靶标：Candida albicans External Id：CHEMBL4296189

实验名称：Antibacterial activity against Staphylococcus aureus MRSA ATCC 43300 (CO-ADD:GP_020);... 来源：ChEMBL 靶标：Staphylococcus aureus External Id：CHEMBL4296184

实验名称：Antibacterial activity against Klebsiella pneumoniae MDR ATCC 70063 (CO-ADD:GN_003); ... 来源：ChEMBL 靶标：Klebsiella pneumoniae External Id：CHEMBL4296186

实验名称：Antibacterial activity against Escherichia coli ATCC 25922 (CO-ADD:GN_001); MIC in CA... 来源：ChEMBL 靶标：Escherichia coli External Id：CHEMBL4296185

实验名称：Antibacterial activity against Pseudomonas aeruginosa PAO397 [PAO1 d(mexAB-oprM) d(me... 来源：ChEMBL 靶标：Pseudomonas aeruginosa External Id：CHEMBL4296802

实验名称：Haemolysis of human Red Blood Cells (CO-ADD:HA_150); HC10, by OD(450) 来源：ChEMBL 靶标：Erythrocyte External Id：CHEMBL4296784

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H-γ-D-Glu-Trp-OH英文别名

• SCV-07
• Golotimod