AGN 194310

更新时间：2025-09-04 13:53:32

AGN 194310结构式	常用名	AGN 194310	英文名	AGN 194310
	CAS号	229961-45-9	分子量	424.554
	密度	1.3±0.1 g/cm3	沸点	598.1±50.0 °C at 760 mmHg
	分子式	C₂₈H₂₄O₂S	熔点	N/A
	MSDS	N/A	闪点	315.5±30.1 °C

AGN 194310用途

AGN 194310(VTP-194310)是RAR激动剂,对RARα/β/γ的Kd分别为3/2/5 nM。

中文名	AGN 194310
英文名	AGN 194310
英文别名	更多

描述	AGN 194310(VTP-194310)是RAR激动剂,对RARα/β/γ的Kd分别为3/2/5 nM。
相关类别	信号通路 >> 代谢酶/蛋白酶 >> RAR/RXR 研究领域 >> 癌症
参考文献	[1]. Johnson AT, et al. Synthesis and biological activity of high-affinity retinoic acid receptor antagonists. Bioorg Med Chem. 1999 Jul;7(7):1321-38. [2]. Hammond LA, et al. Antagonists of retinoic acid receptors (RARs) are potent growth inhibitors of prostate carcinoma cells. Br J Cancer. 2001 Aug 3;85(3):453-62. [3]. Austenaa LM, et al. Vitamin A status significantly alters nuclear factor-kappaB activity assessed by in vivo imaging. FASEB J. 2004 Aug;18(11):1255-7. [4]. Walkley CR, et al. Retinoic acid receptor antagonism in vivo expands the numbers of precursor cells during granulopoiesis. Leukemia. 2002 Sep;16(9):1763-72.

描述

AGN 194310(VTP-194310)是RAR激动剂,对RARα/β/γ的Kd分别为3/2/5 nM。

相关类别

信号通路 >> 代谢酶/蛋白酶 >> RAR/RXR

研究领域 >> 癌症

参考文献

[1]. Johnson AT, et al. Synthesis and biological activity of high-affinity retinoic acid receptor antagonists. Bioorg Med Chem. 1999 Jul;7(7):1321-38.

[2]. Hammond LA, et al. Antagonists of retinoic acid receptors (RARs) are potent growth inhibitors of prostate carcinoma cells. Br J Cancer. 2001 Aug 3;85(3):453-62.

[3]. Austenaa LM, et al. Vitamin A status significantly alters nuclear factor-kappaB activity assessed by in vivo imaging. FASEB J. 2004 Aug;18(11):1255-7.

[4]. Walkley CR, et al. Retinoic acid receptor antagonism in vivo expands the numbers of precursor cells during granulopoiesis. Leukemia. 2002 Sep;16(9):1763-72.

密度	1.3±0.1 g/cm3
沸点	598.1±50.0 °C at 760 mmHg
分子式	C₂₈H₂₄O₂S
分子量	424.554
闪点	315.5±30.1 °C
精确质量	424.149689
LogP	9.56
InChIKey	LHUPKWKWYWOMSK-UHFFFAOYSA-N
SMILES	CCc1ccc(C2=CC(C)(C)Sc3ccc(C#Cc4ccc(C(=O)O)cc4)cc32)cc1
蒸汽压	0.0±1.8 mmHg at 25°C
折射率	1.683
储存条件	2-8℃

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4-{[4-(4-Ethylphenyl)-2,2-dimethyl-2H-thiochromen-6-yl]ethynyl}benzoic acid