IDO1/2-IN-1

• 常用名: IDO1/2-IN-1
• 英文名: IDO1/2-IN-1
• CAS号: 2310286-45-2
• 分子量: 485.27
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₆H₁₈BrFN₈O₄
• 熔点: N/A
• 闪点: N/A

IDO1/2-IN-1用途

IDO1/2-IN-1(化合物4t)是第一种有效的IDO1/IDO2双重抑制剂,IDO1和IDO2的IC50分别为28 nM和144 nM。IDO1/2-IN-1具有抗肿瘤活性。口服活性[1]。

IDO1/2-IN-1名称

• 英文名: IDO1/2-IN-1

IDO1/2-IN-1生物活性

• 描述: IDO1/2-IN-1(化合物4t)是第一种有效的IDO1/IDO2双重抑制剂,IDO1和IDO2的IC50分别为28 nM和144 nM。IDO1/2-IN-1具有抗肿瘤活性。口服活性[1]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 代谢酶/蛋白酶 >> 吲哚胺2,3-二氧化酶(IDO)
• 靶点实验:

  IDO1:28 nM (IC50)

  IDO2:144 nM (IC50)

• 参考文献:

  [1]. He X, et al. Discovery of the First Potent IDO1/IDO2 Dual Inhibitors: A Promising Strategy for Cancer Immunotherapy. J Med Chem. 2021;64(24):17950-17968.

IDO1/2-IN-1物理化学性质

• 分子式: C₁₆H₁₈BrFN₈O₄
• 分子量: 485.27

IDO1/2-IN-1靶点实验

查看更多实验

实验名称：In vivo inhibition of TDO in BALB/c mouse xenografted with human HCT-116 cells assess... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5058060

实验名称：Inhibition of PAK6 (unknown origin) at 1 uM 来源：ChEMBL 靶标：Serine/threonine-protein kinase PAK 6 External Id：CHEMBL5058315

实验名称：Inhibition of ABL1 (unknown origin) at 1 uM 来源：ChEMBL 靶标：Tyrosine-protein kinase ABL1 External Id：CHEMBL5058066

实验名称：Inhibition of p38gamma (unknown origin) at 1 uM 来源：ChEMBL 靶标：Mitogen-activated protein kinase 12 External Id：CHEMBL5058307

实验名称：Antitumor immunity in BALB/c mouse xenografted with human HCT-116 cells assessed as i... 来源：ChEMBL 靶标：HCT-116 External Id：CHEMBL5058051

实验名称：In vivo inhibition of IDO1 in BALB/c mouse xenografted with human HCT-116 cells asses... 来源：ChEMBL 靶标：Indoleamine 2,3-dioxygenase 1 External Id：CHEMBL5058057

实验名称：Antitumor immunity in BALB/c mouse xenografted with human HCT-116 cells assessed as i... 来源：ChEMBL 靶标：HCT-116 External Id：CHEMBL5058046

实验名称：Antitumor immunity in BALB/c mouse xenografted with human HCT-116 cells assessed as i... 来源：ChEMBL 靶标：HCT-116 External Id：CHEMBL5058045

实验名称：Antitumor immunity in BALB/c mouse xenografted with human HCT-116 cells assessed as i... 来源：ChEMBL 靶标：HCT-116 External Id：CHEMBL5058044

实验名称：Antitumor immunity in BALB/c mouse xenografted with human HCT-116 cells assessed as i... 来源：ChEMBL 靶标：HCT-116 External Id：CHEMBL5058043

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