CCG-232964

更新时间：2026-07-17 09:48:28

CCG-232964用途

CCG-232964 是一种有口服活性的 Rho/MRTF/SRF 抑制剂。CCG-232964 抑制 LPA 诱导的 CTGF 基因表达。

英文名	CCG-232964

描述	CCG-232964 是一种有口服活性的 Rho/MRTF/SRF 抑制剂。CCG-232964 抑制 LPA 诱导的 CTGF 基因表达。
相关类别	研究领域 >> 癌症信号通路 >> 细胞周期/DNA损伤 >> 岩石信号通路 >> G 蛋白偶联受体/G 蛋白 >> 拉斯研究领域 >> 神经疾病信号通路 >> 干细胞及 Wnt 通路 >> 岩石信号通路 >> TGF-beta/Smad 信号通路 >> 岩石
参考文献	[1]. Kahl, Dylan, et al. 5-Aryl-1,3,4-oxadiazol-2-ylthioalkanoic Acids: A Highly Potent New Class of Inhibitors of Rho/Myocardin-Related Transcription Factor (MRTF)/Serum Reponse Factor (SRF)-Mediated Gene Transcription as Potential Antifibrotic Agents for Scleroderma. Journal of Medicinal Chemistry, (), acs.jmedchem.8b01772–.

分子式	C₁₅H₁₅ClN₂O₃S
分子量	338.81

实验名称：Half-life in CD-1 mouse at 3 mg/kg, iv by LC-MS/MS analysis
来源：ChEMBL
靶标：N/A
External Id：CHEMBL4386346

实验名称：Half-life in CD-1 mouse at 3 mg/kg, po by LC-MS/MS analysis
来源：ChEMBL
靶标：N/A
External Id：CHEMBL4386347

实验名称：Half-life in CD-1 mouse at 10 mg/kg, po by LC-MS/MS analysis
来源：ChEMBL
靶标：N/A
External Id：CHEMBL4386348

实验名称：AUC in CD-1 mouse at 30 mg/kg, po by LC-MS/MS analysis
来源：ChEMBL
靶标：N/A
External Id：CHEMBL4386350

实验名称：Oral bioavailability in CD-1 mouse at 10 mg/kg by LC-MS/MS analysis
来源：ChEMBL
靶标：N/A
External Id：CHEMBL4386369

实验名称：Inhibition of Rho/MRTF/SRF pathway in human primary dermal fibroblasts assessed as re...
来源：ChEMBL
靶标：N/A
External Id：CHEMBL4386370

实验名称：Cytotoxicity against human PC3 cells assessed as reduction in cell viability up to 10...
来源：ChEMBL
靶标：PC-3
External Id：CHEMBL4386338

实验名称：Half-life in CD-1 mouse liver microsomes at 1 uM in presence of NADPH by LC-MS/MS ana...
来源：ChEMBL
靶标：N/A
External Id：CHEMBL4386339

实验名称：Inhibition of Rho/MRTF/SRF pathway in human primary dermal fibroblasts assessed as re...
来源：ChEMBL
靶标：N/A
External Id：CHEMBL4386371

实验名称：Cytotoxicity against HEK293T cells assessed as reduction in cell viability up to 100 ...
来源：ChEMBL
靶标：HEK-293T
External Id：CHEMBL4386372

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