二氟孕甾丁酯

• 常用名: 二氟孕甾丁酯
• 英文名: Difluprednate
• CAS号: 23674-86-4
• 分子量: 508.552
• 密度: 1.3±0.1 g/cm3
• 沸点: 600.3±55.0 °C at 760 mmHg
• 分子式: C₂₇H₃₄F₂O₇
• 熔点: 192 - 194ºC
• 闪点: 316.9±31.5 °C

二氟孕甾丁酯用途

Difluprednate(Durezol)是一种皮质类固醇,可作用于术后眼睛疼痛和炎症。

二氟孕甾丁酯名称

• 中文名: 二氟孕甾丁酯
• 英文名: [(6S,8S,9R,10S,11S,13S,14S,17R)-17-(2-acetyloxyacetyl)-6,9-difluoro-11-hydroxy-10,13-dimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] butanoate
• 中文别名: 二氟泼尼酯 | 双氟泼尼酯

二氟孕甾丁酯生物活性

• 描述: Difluprednate(Durezol)是一种皮质类固醇,可作用于术后眼睛疼痛和炎症。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 炎症/免疫
• 参考文献:

  [1]. Difluprednate, From Wikipedia

二氟孕甾丁酯物理化学性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 600.3±55.0 °C at 760 mmHg
• 熔点: 192 - 194ºC
• 分子式: C₂₇H₃₄F₂O₇
• 分子量: 508.552
• 闪点: 316.9±31.5 °C
• 精确质量: 508.227264
• PSA: 106.97000
• LogP: 3.67
• InChIKey: WYQPLTPSGFELIB-JTQPXKBDSA-N
• SMILES: CCCC(=O)OC1(C(=O)COC(C)=O)CCC2C3CC(F)C4=CC(=O)C=CC4(C)C3(F)C(O)CC21C
• 外观性状: 固体;White to Light yellow powder to crystal
• 蒸汽压: 0.0±3.9 mmHg at 25°C
• 折射率: 1.545
• 储存条件: 0-10°C;避免加热
• 水溶解性: 水溶性：不溶；水溶解度：0.008 g/l ；可溶于：乙醇,甲醇,氯仿；极微溶：二乙醚

二氟孕甾丁酯毒性和生态

二氟孕甾丁酯安全信息

• 个人防护装备: Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
• 危害码 (欧洲): Xn
• 危险品运输编码: NONH for all modes of transport
• WGK德国: 2.0
• RTECS号: TU3831500

二氟孕甾丁酯靶点实验

查看更多实验

实验名称：Primary cell-based high-throughput screening assay for identification of compounds th... 来源：Johns Hopkins Ion Channel Center 靶标：regulator of G-protein signaling 4 isoform 2 [Homo sapiens] External Id：JHICC_RGS_Act_HTS

实验名称：Luminescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：mu-type opioid receptor isoform MOR-1 [Homo sapiens] External Id：OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN

实验名称：QFRET-based biochemical primary high throughput screening assay to identify exosite i... 来源：The Scripps Research Institute Molecular Screening Center 靶标：disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] External Id：ADAM17_INH_QFRET_1536_1X%INH PRUN

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

实验名称：uHTS identification of small molecule activators of the adaptive arm of the Unfolded ... 来源：Burnham Center for Chemical Genomics 靶标：N/A External Id：BCCG-A405-UPR-XBP1-PrimaryAgonist-Assay

实验名称：High throughput fluorescence intensity-based biochemical assay to screen for small mo... 来源：University of Pittsburgh Molecular Library Screening Center 靶标：furin (paired basic amino acid cleaving enzyme), isoform CRA_a [Homo sapiens] External Id：MH080376 Biochemical HTS for Inhibitors of the Proprotein Convertase Furin.

实验名称：Fluorescence polarization to screen for inhibitor that competite the binding of FadD2... 来源：Broad Institute 靶标：FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE) External Id：2147-01_Inhibitor_SinglePoint_HTS_Activity

实验名称：Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfect... 来源：Broad Institute 靶标：N/A External Id：Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfected HEK293 cells Inhibition - 7011-01_Antagonist_SinglePoint_HTS_Activity

实验名称：Flow Cytometric HTS Screen for inhibitors of the ABC transporter ABCB6 for Validation... 来源：NMMLSC 靶标：ATP-binding cassette sub-family B member 6, mitochondrial [Homo sapiens] External Id：UNMCMD_ABCB6_1o_ValidationSet

实验名称：Primary Screen Inhibitors of CD40 Signaling in BL2 Cells Measured in Cell-Based Syste... 来源：Broad Institute 靶标：N/A External Id：7124-01_Inhibitor_SinglePoint_HTS_Activity

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二氟孕甾丁酯英文别名

• Butanoic acid, (6α,11β)-21-(acetyloxy)-6,9-difluoro-11-hydroxy-3,20-dioxopregna-1,4-dien-17-yl ester
• Myser
• Difluoroprednisolone butyrate acetate
• (6α,11β)-21-Acetoxy-6,9-difluoro-11-hydroxy-3,20-dioxopregna-1,4-dien-17-yl butyrate
• UNII-S8A06QG2QE
• Difluprednate
• 6a,9-Difluoro-11b,17,21-trihydroxypregna-1,4-diene-3,20-dione 21-Acetate 17-Butyrate
• (6a,11b)-21-(Acetyloxy)-6,9-difluoro-11-hydroxy-17-(1-oxobutoxy)pregna-1,4-diene-3,20-dione
• 6α,9-Difluoro-11β,17,21-trihydroxypregna-1,4-diene-3,20-dione 21-acetate 17-butyrate
• (6α,11β)-21-(acetyloxy)-6,9-difluoro-11-hydroxy-3,20-dioxopregna-1,4-dien-17-yl butanoate
• 6ALPHA,9ALPHA-DIFLUOROPREDNISOLONE 21-ACETATE 17-BUTYRATE
• Durezol
• 6a,9a-Difluoroprednisolone-21-acetate-17-butyrate
• DFBA
• Epitopic