二氟孕甾丁酯
二氟孕甾丁酯结构式
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常用名 | 二氟孕甾丁酯 | 英文名 | Difluprednate |
|---|---|---|---|---|
| CAS号 | 23674-86-4 | 分子量 | 508.552 | |
| 密度 | 1.3±0.1 g/cm3 | 沸点 | 600.3±55.0 °C at 760 mmHg | |
| 分子式 | C27H34F2O7 | 熔点 | 192 - 194ºC | |
| MSDS | 中文版 美版 | 闪点 | 316.9±31.5 °C |
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Topical cyclosporine a 1% for the treatment of chronic ocular surface inflammation.
Eye Contact Lens 40(5) , 283-8, (2014) To evaluate the use of topical cyclosporine A (CsA) 1% emulsion in the treatment of chronic ocular surface inflammation (OSI).We conducted a retrospective chart review of patients with various forms of OSI treated with topical CsA 1% from 2001 to 2012.Twenty-... |
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Determination of natural and synthetic glucocorticoids in effluent of sewage treatment plants using ultrahigh performance liquid chromatography-tandem mass spectrometry.
Environ. Sci. Pollut. Res. Int. 22 , 14127-35, (2015) A sensitive and comprehensive analytical method for glucocorticoids (GCs) in water samples was developed and applied to effluent of sewage treatment plants (STPs). In the present study, totally 10 natural and synthetic GCs, including cortisol, betamethasone v... |
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Pharmacokinetic features of difluprednate ophthalmic emulsion in rabbits as determined by glucocorticoid receptor-binding bioassay.
J. Ocul. Pharmacol. Ther. 27(1) , 29-34, (2011) Difluprednate (6α,9-difluoro-11β,17,21-trihydroxy-1,4-pregnadiene-3,20-dione 21-acetate 17-butyrate, DFBA) has long been used as an anti-inflammatory dermatological agent. The main objectives of the current study were to evaluate the pharmacokinetic and pharm... |
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Difluprednate 0.05% versus prednisolone acetate 1% for endogenous anterior uveitis: a phase III, multicenter, randomized study.
Invest. Ophthalmol. Vis. Sci. 55(5) , 2993-3002, (2014) Endogenous anterior uveitis (AU), when untreated, may lead to vision loss. This study compared the safety and efficacy of difluprednate versus prednisolone acetate for the treatment of this condition.This phase III, double-masked, noninferiority study randomi... |
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Analysis of an anti-inflammatory steroidal drug, difluprednate, in aqueous humor by combination of semi-micro HPLC and column switching method.
J. Pharm. Biomed. Anal. 30(6) , 1735-42, (2003) A specific and sensitive method for the determination for difluprednate (DFBA) and its metabolite (deacetylated DFBA, DFB) in aqueous humor was developed. DFBA and DFB were initially absorbed on a Pinkerton-type column, then analyzed by high-performance liqui... |
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Hypopyon uveitis following LASIK in a patient with ulcerative colitis.
J. Refract. Surg. 28(8) , 589-91, (2012) To present a case of unilateral hypopyon uveitis that began 15 days after uneventful bilateral LASIK in a 24-year-old man with an undisclosed history of ulcerative colitis.Case report.The hypopyon uveitis completely resolved after treatment with aggressive to... |
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A multicenter randomized controlled fellow eye trial of pulse-dosed difluprednate 0.05% versus prednisolone acetate 1% in cataract surgery.
Am. J. Ophthalmol. 152(4) , 609-617.e1, (2011) To compare the effects of 2 corticosteroids on corneal thickness and visual acuity after cataract surgery.Multicenter, randomized, contralateral-eye, double-masked trial.Fifty-two patients (104 eyes) underwent bilateral phacoemulsification. The first eye rand... |
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Vogt-Koyanagi-Harada syndrome in a 6-year-old Hispanic boy.
Pediatr. Dermatol. 29(2) , 191-4, (2012) A 6-year-old Hispanic boy presented to the ophthalmology department with complaints of pain, photophobia, and blurry vision of both eyes. He was found to have bilateral granulomatous panuveitis, cataracts, and high intraocular pressures. He later developed mu... |
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Ocular distribution of difluprednate ophthalmic emulsion 0.05% in rabbits.
J. Ocul. Pharmacol. Ther. 27(1) , 43-9, (2011) To evaluate ocular distribution and excretion of tritium-labeled difluprednate ((3)H-DFBA) ophthalmic emulsion 0.05% after a single or repeated instillation to pigmented rabbit eyes.(3)H-DFBA ophthalmic emulsion 0.05% was instilled in the right eyes of pigmen... |
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Effects of twice-daily topical difluprednate 0.05% emulsion in a child with pars planitis.
Ocul. Immunol. Inflamm. 19(1) , 84-5, (2011) To report the effects of twice-daily difluprednate in a child with pars planitis (PP).Case report.PP was controlled with topical difluprednate for 1 year. Then an atypical pattern of steroid response--delayed, relatively sudden onset of recalcitrant ocular hy... |