ROS-generating agent 1

• 常用名: ROS-generating agent 1
• 英文名: ROS-generating agent 1
• CAS号: 2369030-41-9
• 分子量: 411.34
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₁H₁₅F₆NO
• 熔点: N/A
• 闪点: N/A

ROS-generating agent 1用途

ROS产生剂1(化合物2c)共价修饰TrxR的Sec-498残基以产生ROS。ROS生成剂1降低细胞内TrxR蛋白水平。ROS产生剂1导致NCI-H460细胞的ROS依赖性凋亡和脱铁性贫血。ROS生成剂1具有抗癌活性[1]。

ROS-generating agent 1名称

• 英文名: ROS-generating agent 1

ROS-generating agent 1生物活性

• 描述: ROS产生剂1(化合物2c)共价修饰TrxR的Sec-498残基以产生ROS。ROS生成剂1降低细胞内TrxR蛋白水平。ROS产生剂1导致NCI-H460细胞的ROS依赖性凋亡和脱铁性贫血。ROS生成剂1具有抗癌活性[1]。
• 相关类别:
  信号通路 >> 细胞凋亡 >> 细胞凋亡
  研究领域 >> 癌症
  信号通路 >> 细胞凋亡 >> Ferroptosis
• 参考文献:

  [1]. Liu X, et al. Tumor killing by a dietary curcumin mono-carbonyl analog that works as a selective ROS generator via TrxR inhibition. Eur J Med Chem. 2023 Mar 15;250:115191.

ROS-generating agent 1物理化学性质

• 分子式: C₂₁H₁₅F₆NO
• 分子量: 411.34

ROS-generating agent 1靶点实验

查看更多实验

实验名称：Induction of ferroptosis in human NCI-H460 cells assessed as increase in intracellula... 来源：ChEMBL 靶标：NCI-H460 External Id：CHEMBL5387636

实验名称：Induction of ferroptosis in human NCI-H460 cells assessed as fold increase in MDA lev... 来源：ChEMBL 靶标：NCI-H460 External Id：CHEMBL5387635

实验名称：Induction of ferroptosis in human NCI-H460 cells assessed as increase in intracellula... 来源：ChEMBL 靶标：NCI-H460 External Id：CHEMBL5387634

实验名称：Induction of ferroptosis in human NCI-H460 cells assessed as increase in MDA levels a... 来源：ChEMBL 靶标：NCI-H460 External Id：CHEMBL5387633

实验名称：Induction of ferroptosis in human NCI-H460 cells assessed as increase in MDA levels a... 来源：ChEMBL 靶标：NCI-H460 External Id：CHEMBL5387632

实验名称：Upregulation of caspase-3 activation in human NCI-H460 cells at 1 to 2 uM measured af... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5387631

实验名称：Upregulation of caspase-9 activation in human NCI-H460 cells at 1 to 2 uM measured af... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5387630

实验名称：Upregulation of Bax expression in human NCI-H460 cells at 1 to 2 uM measured after 48... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5387629

实验名称：Downregulation of Bcl-2 expression in human NCI-H460 cells at 1 to 2 uM measured afte... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5387628

实验名称：Upregulation of caspase-3 activation in human NCI-H460 cells at 1 to 2 uM measured af... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5387627

共61条，当前第1页，共7页

1

2

3

4

5