MS5033

• 常用名: MS5033
• 英文名: MS5033
• CAS号: 2376137-29-8
• 分子量: 1044.59
• 密度: N/A
• 沸点: N/A
• 分子式: C₅₁H₆₆ClN₁₁O₁₁
• 熔点: N/A
• 闪点: N/A

MS5033用途

MS5033是一种有效的基于PROTAC的AKT(蛋白激酶B)降解剂,在PC3细胞中DC50为430 nM【1】。

MS5033名称

• 英文名: MS5033

MS5033生物活性

• 描述: MS5033是一种有效的基于PROTAC的AKT(蛋白激酶B)降解剂,在PC3细胞中DC50为430 nM【1】。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> PI3K/Akt/mTOR 信号通路 >> AKT
  信号通路 >> 蛋白裂解靶向嵌合体 >> PROTAC
• 参考文献:

  [1]. Yu XF, et, al. Discovery of Potent, Selective, and In Vivo Efficacious AKT Kinase Protein Degraders via Structure-Activity Relationship Studies. J Med Chem. 2022 Feb 24;65(4):3644-3666.

MS5033物理化学性质

• 分子式: C₅₁H₆₆ClN₁₁O₁₁
• 分子量: 1044.59

MS5033靶点实验

查看更多实验

实验名称：Protac activity at CRBN/AKT in human PC-3 cells assessed as reduction in AKT protein ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5048568

实验名称：Protac activity at CRBN/AKT in human PC-3 cells assessed as reduction in AKT protein ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5048567

实验名称：Protac activity at CRBN/AKT in human BT-474 cells assessed as reduction in AKT protei... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5048573

实验名称：Protac activity at CRBN/AKT in human PC-3 cells assessed as reduction in AKT protein ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5048603

实验名称：Protac activity at CRBN/AKT in human PC-3 cells assessed as reduction in AKT protein ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5048602

实验名称：Protac activity at CRBN/AKT in human PC-3 cells assessed as reduction in AKT protein ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5048608

实验名称：Protac activity at CRBN/AKT in human BT-474 cells assessed as inhibition of S6 riboso... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5048574

实验名称：Binding affinity to DNA-tagged AKT3 (unknown origin) assessed as dissociation constan... 来源：ChEMBL 靶标：RAC-gamma serine/threonine-protein kinase External Id：CHEMBL5048580

实验名称：Binding affinity to DNA-tagged AKT2 (unknown origin) assessed as dissociation constan... 来源：ChEMBL 靶标：RAC-beta serine/threonine-protein kinase External Id：CHEMBL5048579

实验名称：Binding affinity to DNA-tagged AKT1 (unknown origin) assessed as dissociation constan... 来源：ChEMBL 靶标：RAC-alpha serine/threonine-protein kinase External Id：CHEMBL5048578

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