TRPA1-IN-1

• 常用名: TRPA1-IN-1
• 英文名: TRPA1-IN-1
• CAS号: 2376824-92-7
• 分子量: 412.83
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₉H₁₇ClN₆O₃
• 熔点: N/A
• 闪点: N/A

TRPA1-IN-1用途

TRPA1-IN-1是一种有效的、选择性的、口服生物利用的TRPA1小分子拮抗剂。

TRPA1-IN-1名称

• 英文名: TRPA1-IN-1

TRPA1-IN-1生物活性

• 描述: TRPA1-IN-1是一种有效的、选择性的、口服生物利用的TRPA1小分子拮抗剂。
• 相关类别:
  信号通路 >> 跨膜转运 >> TRP频道
  研究领域 >> 其他
• 参考文献:

  [1]. Terrett JA, et al. Tetrahydrofuran-Based Transient Receptor Potential Ankyrin 1 (TRPA1) Antagonists: Ligand-Based Discovery, Activity in a Rodent Asthma Model, and Mechanism-of-Action via Cryogenic Electron Microscopy. J Med Chem. 2021 Apr 8;64(7):3843-3869.

TRPA1-IN-1物理化学性质

• 分子式: C₁₉H₁₇ClN₆O₃
• 分子量: 412.83
• InChIKey: UGLQOTZNBCEHHB-GXTWGEPZSA-N
• SMILES: Cn1cnc2ncn(Cc3nc(C4COC(c5ccc(Cl)cc5)C4)no3)c(=O)c21

TRPA1-IN-1靶点实验

查看更多实验

实验名称：Antinociceptive activity against AITC-induced rat pain model assessed as nocifensive ... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL5055756

实验名称：Half life in rat at 1 mg/kg 来源：ChEMBL 靶标：N/A External Id：CHEMBL5055755

实验名称：Clearance in rat at 1 mg/kg 来源：ChEMBL 靶标：N/A External Id：CHEMBL5055762

实验名称：Volume of distribution at steady stare in rat at 1 mg/kg 来源：ChEMBL 靶标：N/A External Id：CHEMBL5055761

实验名称：Unbound Volume of distribution at steady state in rat at 1 mg/kg 来源：ChEMBL 靶标：N/A External Id：CHEMBL5055760

实验名称：Antagonist activity at rat TRPA1 expressed in CHO cells assessed as cinnamaldehyde-in... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5055750

实验名称：Metabolic stability in rat liver microsomes assessed as clearance by LC/MS-MS analysi... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5055749

实验名称：Metabolic stability in human liver microsomes assessed as clearance by LC/MS-MS analy... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5055748

实验名称：Protein binding in rat plasma 来源：ChEMBL 靶标：N/A External Id：CHEMBL5055754

实验名称：Protein binding in human plasma 来源：ChEMBL 靶标：N/A External Id：CHEMBL5055753

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