CCT373566

更新时间：2025-08-26 10:44:44

CCT373566结构式	常用名	CCT373566	英文名	CCT373566
	CAS号	2378853-66-6	分子量	547.00
	密度	N/A	沸点	N/A
	分子式	C₂₆H₂₉ClF₂N₆O₃	熔点	N/A
	MSDS	N/A	闪点	N/A

CCT373566用途

CCT373566是转录阻遏因子BCL6的有效口服降解物,IC50为2.2 nM。CCT373566在体外显示出强大的抗增殖功效,并在体内减少肿瘤生长[1]。

英文名	CCT373566

描述	CCT373566是转录阻遏因子BCL6的有效口服降解物,IC50为2.2 nM。CCT373566在体外显示出强大的抗增殖功效,并在体内减少肿瘤生长[1]。
相关类别	信号通路 >> 细胞凋亡 >> Bcl-2家族研究领域 >> 癌症
参考文献	[1]. Huckvale R, et, al. Improved Binding Affinity and Pharmacokinetics Enable Sustained Degradation of BCL6 In Vivo. J Med Chem. 2022 Jun 23;65(12):8191-8207.

分子式	C₂₆H₂₉ClF₂N₆O₃
分子量	547.00

实验名称：Passive membrane permeability of compound in phosphate buffered saline at pH 7.4 at 1...
来源：ChEMBL
靶标：N/A
External Id：CHEMBL5168572

实验名称：HTRF Assay from US Patent US20230287003: "BCL6 INHIBITORS"
来源：BindingDB
靶标：N/A
External Id：BindingDB_11468_1

实验名称：Degradation of BCL6 in human KARPAS-422 cells assessed as maximal efficacy by MSD ass...
来源：ChEMBL
靶标：B-cell lymphoma 6 protein
External Id：CHEMBL5168574

实验名称：Fraction unbound in IMDM medium at 5 uM incubated for 4 hrs by ESI-LCMS/MS based UPLC...
来源：ChEMBL
靶标：N/A
External Id：CHEMBL5168569

实验名称：Intrinsic clearance in Sprague-Dawley rat liver microsomes at 1 uM preincubated for 1...
来源：ChEMBL
靶标：N/A
External Id：CHEMBL5168571

实验名称：Intrinsic clearance in human liver microsomes at 1 uM preincubated for 10 mins and me...
来源：ChEMBL
靶标：N/A
External Id：CHEMBL5168570

实验名称：Intrinsic clearance in CD-1 mouse liver microsomes at 1 uM preincubated for 10 mins a...
来源：ChEMBL
靶标：N/A
External Id：CHEMBL5168565

实验名称：Degradation of BCL6 in human OCI-Ly1 cells assessed as maximal efficacy incubated for...
来源：ChEMBL
靶标：B-cell lymphoma 6 protein
External Id：CHEMBL5168564

实验名称：Lipophilicity, logD of compound at pH 7.4 by UV-vis detection based HPLC analysis
来源：ChEMBL
靶标：N/A
External Id：CHEMBL5168566

实验名称：Toxicity in SCID mouse xenografted with human OCI-Ly1 cells assessed as noticeable ad...
来源：ChEMBL
靶标：N/A
External Id：CHEMBL5168560

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