CCT373567

• 常用名: CCT373567
• 英文名: CCT373567
• CAS号: 2378853-67-7
• 分子量: 547.00
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₆H₂₉ClF₂N₆O₃
• 熔点: N/A
• 闪点: N/A

CCT373567用途

CCT373567是转录阻遏因子BCL6的有效降解物,IC50为2.9 nM。CCT373567具有抗增殖活性[1]。

CCT373567名称

• 英文名: CCT373567

CCT373567生物活性

• 描述: CCT373567是转录阻遏因子BCL6的有效降解物,IC50为2.9 nM。CCT373567具有抗增殖活性[1]。
• 相关类别:
  信号通路 >> 细胞凋亡 >> Bcl-2家族
  研究领域 >> 癌症
• 参考文献:

  [1]. Huckvale R, et, al. Improved Binding Affinity and Pharmacokinetics Enable Sustained Degradation of BCL6 In Vivo. J Med Chem. 2022 Jun 23;65(12):8191-8207.

CCT373567物理化学性质

• 分子式: C₂₆H₂₉ClF₂N₆O₃
• 分子量: 547.00

CCT373567靶点实验

查看更多实验

实验名称：Passive membrane permeability of compound in phosphate buffered saline at pH 7.4 at 1... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5168572

实验名称：HTRF Assay from US Patent US20230287003: "BCL6 INHIBITORS" 来源：BindingDB 靶标：N/A External Id：BindingDB_11468_1

实验名称：Intrinsic clearance in Sprague-Dawley rat liver microsomes at 1 uM preincubated for 1... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5168571

实验名称：Intrinsic clearance in human liver microsomes at 1 uM preincubated for 10 mins and me... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5168570

实验名称：Intrinsic clearance in CD-1 mouse liver microsomes at 1 uM preincubated for 10 mins a... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5168565

实验名称：Degradation of BCL6 in human OCI-Ly1 cells assessed as maximal efficacy incubated for... 来源：ChEMBL 靶标：B-cell lymphoma 6 protein External Id：CHEMBL5168564

实验名称：Kinetic aqueous solubility of the compound in 4% DMSO/HEPES buffer at pH 8 incubated ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5168567

实验名称：Lipophilicity, logD of compound at pH 7.4 by UV-vis detection based HPLC analysis 来源：ChEMBL 靶标：N/A External Id：CHEMBL5168566

实验名称：Degradation of BCL6 in human OCI-Ly1 cells incubated for 2 hrs by MSD assay 来源：ChEMBL 靶标：B-cell lymphoma 6 protein External Id：CHEMBL5168563

实验名称：Inhibition of N-terminal thioredoxin-His6 tagged human BCL6 BTB domain (5 to 129 resi... 来源：ChEMBL 靶标：B-cell lymphoma 6 protein External Id：CHEMBL5168562

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