LY3154885

• 常用名: LY3154885
• 英文名: LY3154885
• CAS号: 2379422-72-5
• 分子量: 444.35
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₃H₂₃Cl₂N₃O₂
• 熔点: N/A
• 闪点: N/A

LY3154885用途

LY3154885是一种口服活性多巴胺D1受体阳性变构调节剂(PAM)。LY3154885改善了药物相互作用(DDI)风险状况[1]。

LY3154885名称

• 英文名: LY3154885

LY3154885生物活性

• 描述: LY3154885是一种口服活性多巴胺D1受体阳性变构调节剂(PAM)。LY3154885改善了药物相互作用(DDI)风险状况[1]。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 多巴胺受体
  信号通路 >> 神经信号通路 >> 多巴胺受体
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Junliang Hao, et al. Synthesis and Preclinical Characterization of LY3154885, a Human Dopamine D1 Receptor Positive Allosteric Modulator with an Improved Nonclinical Drug-Drug Interaction Risk Profile. J Med Chem. 2022 Mar 10;65(5):3786-3797.

LY3154885物理化学性质

• 分子式: C₂₃H₂₃Cl₂N₃O₂
• 分子量: 444.35
• InChIKey: MJDOWJUPBHLXIH-GOEBONIOSA-N
• SMILES: CC1c2cccc(-c3cnn(C)c3)c2CC(CO)N1C(=O)Cc1c(Cl)cccc1Cl

LY3154885靶点实验

查看更多实验

实验名称：Induction of CYP3A4 in human hepatocytes assessed as maximum efficacy relative to con... 来源：ChEMBL 靶标：Cytochrome P450 3A4 External Id：CHEMBL5104734

实验名称：Solubility of compound at pH 6 by HTSA assay 来源：ChEMBL 靶标：N/A External Id：CHEMBL5104735

实验名称：Positive allosteric modulation of human D1 receptor in HEK293 cells assessed as leftw... 来源：ChEMBL 靶标：D(1A) dopamine receptor External Id：CHEMBL5104736

实验名称：Positive allosteric modulation of human D1 receptor in HEK293 cells assessed as incre... 来源：ChEMBL 靶标：D(1A) dopamine receptor External Id：CHEMBL5104730

实验名称：Positive allosteric modulation of human D1 receptor in HEK293 cells assessed as incre... 来源：ChEMBL 靶标：D(1A) dopamine receptor External Id：CHEMBL5104731

实验名称：Agonist activity at human D1 receptor in HEK293 cells assessed as increase in cyclic ... 来源：ChEMBL 靶标：D(1A) dopamine receptor External Id：CHEMBL5104732

实验名称：Inhibition of human recombinant CYP2C19 incubated for 2 hrs by RCP assay 来源：ChEMBL 靶标：Cytochrome P450 2C19 External Id：CHEMBL5104726

实验名称：Unbound intrinsic clearance in human hepatocytes assessed as parent compound loss at ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5104727

实验名称：Drug metabolism in human hepatocytes assessed as fraction of Cyp mediated oxidative m... 来源：ChEMBL 靶标：Cytochrome P450 2C19 External Id：CHEMBL5104728

实验名称：Permeability in Q gut model assessed as fraction escaping gut metabolism 来源：ChEMBL 靶标：N/A External Id：CHEMBL5104729

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