PPARγ agonist 4

• 常用名: PPARγ agonist 4
• 英文名: PPARγ agonist 4
• CAS号: 2380227-06-3
• 分子量: 387.45
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₄H₂₂FN₃O
• 熔点: N/A
• 闪点: N/A

PPARγ agonist 4用途

PPARγ激动剂4(化合物18b)是一种有效的选择性PPARγ激动剂。PPARγ激动剂4对非耐药细胞和耐药细胞均无细胞毒性。PPARγ激动剂4仅与伊马替尼联合发挥抗肿瘤效力[1]。

PPARγ agonist 4名称

• 英文名: PPARγ agonist 4

PPARγ agonist 4生物活性

• 描述: PPARγ激动剂4(化合物18b)是一种有效的选择性PPARγ激动剂。PPARγ激动剂4对非耐药细胞和耐药细胞均无细胞毒性。PPARγ激动剂4仅与伊马替尼联合发挥抗肿瘤效力[1]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 细胞周期/DNA损伤 >> PPAR
• 参考文献:

  [1]. Schoepf AM, et al. Overcoming imatinib resistance in chronic myelogenous leukemia cells using non-cytotoxic cell death modulators. Eur J Med Chem. 2020 Jan 1;185:111748.

PPARγ agonist 4物理化学性质

• 分子式: C₂₄H₂₂FN₃O
• 分子量: 387.45
• InChIKey: DSWTXSDWPPFUCE-UHFFFAOYSA-N
• SMILES: CCCc1nc2c(F)cccc2n1Cc1ccc(-c2ccccc2C(N)=O)cc1

PPARγ agonist 4靶点实验

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实验名称：Induction of sensitization to imatinib-induced cytotoxicity in imatinib-resistant hum... 来源：ChEMBL 靶标：K562-IMA[r] External Id：CHEMBL4376388

实验名称：Cytotoxicity against human HS5 cells assessed as cell death at 10 uM after 72 hrs by ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4376389

实验名称：Cytotoxicity against human K562 cells assessed as cell death at 10 uM after 72 hrs by... 来源：ChEMBL 靶标：K562 External Id：CHEMBL4376390

实验名称：Cytotoxicity against African green monkey COS7 cells assessed as effect on cell metab... 来源：ChEMBL 靶标：COS-7 External Id：CHEMBL4376391

实验名称：Induction of sensitization to imatinib-induced cytotoxicity in imatinib-resistant hum... 来源：ChEMBL 靶标：K562-IMA[r] External Id：CHEMBL4376394

实验名称：Induction of sensitization to imatinib-induced cytotoxicity in imatinib-resistant hum... 来源：ChEMBL 靶标：K562-IMA[r] External Id：CHEMBL4376395

实验名称：Transactivation of Gal4-fused human PPARgamma transfected in COS7 cells co-transfecte... 来源：ChEMBL 靶标：Peroxisome proliferator-activated receptor gamma External Id：CHEMBL4376380

实验名称：Solubility of compound in water at >20 uM 来源：ChEMBL 靶标：N/A External Id：CHEMBL4376381

实验名称：Transactivation of Gal4-fused human PPARgamma transfected in COS7 cells co-transfecte... 来源：ChEMBL 靶标：Peroxisome proliferator-activated receptor gamma External Id：CHEMBL4376382

实验名称：Cytotoxicity against imatinib-resistant human K562-IMA[r] cells assessed as induction... 来源：ChEMBL 靶标：K562-IMA[r] External Id：CHEMBL4376384

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