Nrf2 activator-4

• 常用名: Nrf2 activator-4
• 英文名: Nrf2 activator-4
• CAS号: 2383016-68-8
• 分子量: 468.90
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₃H₂₄ClF₃N₂O₃
• 熔点: N/A
• 闪点: N/A

Nrf2 activator-4用途

Nrf2激活剂-4(化合物20a)是一种高效的口服活性Nrf2激活剂,EC50为0.63µM。Nrf2激活剂-4抑制小胶质细胞中的活性氧物种对抗氧化应激。在东莨菪碱诱导的小鼠模型中,Nrf2激活剂-4有效地恢复了学习和记忆障碍[1]。

Nrf2 activator-4名称

• 英文名: Nrf2 activator-4

Nrf2 activator-4生物活性

• 描述: Nrf2激活剂-4(化合物20a)是一种高效的口服活性Nrf2激活剂,EC50为0.63µM。Nrf2激活剂-4抑制小胶质细胞中的活性氧物种对抗氧化应激。在东莨菪碱诱导的小鼠模型中,Nrf2激活剂-4有效地恢复了学习和记忆障碍[1]。
• 相关类别:
  信号通路 >> NF-κB信号通路 >> KEAP1-Nrf2
  信号通路 >> 蛋白酪氨酸激酶 >> ROS
  研究领域 >> 炎症/免疫
  研究领域 >> 神经疾病
• 靶点实验:

  EC50: 0.63 µM (Nrf2)[1]

• 参考文献:

  [1]. Kim HJ, et al. A novel chalcone derivative as Nrf2 activator attenuates learning and memory impairment in a scopolamine-induced mouse model. Eur J Med Chem. 2020 Jan 1;185:111777.

Nrf2 activator-4物理化学性质

• 分子式: C₂₃H₂₄ClF₃N₂O₃
• 分子量: 468.90
• InChIKey: MLBFDNAGDZEBHA-YGCVIUNWSA-N
• SMILES: CN1CCN(C(=O)COc2ccc(C(=O)C=Cc3ccccc3C(F)(F)F)cc2)CC1.Cl

Nrf2 activator-4靶点实验

查看更多实验

实验名称：Lipophilicity, log P of the compound 来源：ChEMBL 靶标：N/A External Id：CHEMBL4315591

实验名称：Effect on mean number of arm entries in C57BL/6 mouse model of scopolamine-induced am... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL4315590

实验名称：Effective permeability of compound by PAMPA-BBB assay 来源：ChEMBL 靶标：N/A External Id：CHEMBL4315580

实验名称：Cognition enhancing effect in C57BL/6 mouse model of scopolamine-induced amnesia asse... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL4315579

实验名称：Cognition enhancing effect in C57BL/6 mouse model of scopolamine-induced amnesia asse... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL4315578

实验名称：Antioxidant activity in mouse assessed as inhibition of scopolamine-induced reduction... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL4315577

实验名称：Activation of NRF2 in mouse BV2 cells assessed as inhibition of H2O2-induced reductio... 来源：ChEMBL 靶标：Nuclear factor erythroid 2-related factor 2 External Id：CHEMBL4315576

实验名称：Activation of NRF2 in mouse BV2 cells assessed as increase in SOD activity incubated ... 来源：ChEMBL 靶标：Nuclear factor erythroid 2-related factor 2 External Id：CHEMBL4315575

实验名称：Activation of NRF2 in mouse BV2 cells upregulation of SOD1 protein expression incubat... 来源：ChEMBL 靶标：Nuclear factor erythroid 2-related factor 2 External Id：CHEMBL4315574

实验名称：Inhibition of H2O2-stimulated ROS accumulation in mouse BV2 cells preincubated for 24... 来源：ChEMBL 靶标：BV-2 External Id：CHEMBL4315573

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