HCAIX-IN-2

• 常用名: HCAIX-IN-2
• 英文名: HCAIX-IN-2
• CAS号: 2389034-45-9
• 分子量: 452.45
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₉H₁₆N₈O₄S
• 熔点: N/A
• 闪点: N/A

HCAIX-IN-2用途

HCAIX-IN-2(化合物9d)是一种选择性碳酸酐酶抑制剂,hCA IX和hCA XII的Ki值分别为24.6 nM和45.3 nM[1]。

HCAIX-IN-2名称

• 英文名: HCAIX-IN-2

HCAIX-IN-2生物活性

• 描述: HCAIX-IN-2(化合物9d)是一种选择性碳酸酐酶抑制剂,hCA IX和hCA XII的Ki值分别为24.6 nM和45.3 nM[1]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 代谢酶/蛋白酶 >> 碳酸酐酶
• 靶点实验:

  CA I:2481 nM (Ki)

  hCA II:456.2 nM (Ki)

  hCA IX:24.6 nM (Ki)

  hCA XII:45.3 nM (Ki)

• 参考文献:

  [1]. Mohamed A Said, et al. Synthesis, biological and molecular dynamics investigations with a series of triazolopyrimidine/triazole-based benzenesulfonamides as novel carbonic anhydrase inhibitors. Eur J Med Chem. 2020 Jan 1;185:111843.

HCAIX-IN-2物理化学性质

• 分子式: C₁₉H₁₆N₈O₄S
• 分子量: 452.45

HCAIX-IN-2靶点实验

查看更多实验

实验名称：Selectivity index, ratio of Ki for recombinant human carbonic anhydrase-2 to Ki for r... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4316155

实验名称：Selectivity index, ratio of Ki for recombinant human carbonic anhydrase-2 to Ki for r... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4316154

实验名称：Selectivity index, ratio of Ki for recombinant human carbonic anhydrase-1 to Ki for r... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4316153

实验名称：Selectivity index, ratio of Ki for recombinant human carbonic anhydrase-1 to Ki for r... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4316152

实验名称：Inhibition of recombinant human carbonic anhydrase-12 incubated for 15 mins by stoppe... 来源：ChEMBL 靶标：Carbonic anhydrase 12 External Id：CHEMBL4316151

实验名称：Inhibition of recombinant human carbonic anhydrase-9 incubated for 15 mins by stopped... 来源：ChEMBL 靶标：Carbonic anhydrase 9 External Id：CHEMBL4316150

实验名称：Inhibition of recombinant human carbonic anhydrase-2 incubated for 15 mins by stopped... 来源：ChEMBL 靶标：Carbonic anhydrase 2 External Id：CHEMBL4316149

实验名称：NCI human tumor cell line growth inhibition assay. Data for the MCF7 Non-Small Cell L... 来源：DTP/NCI 靶标：N/A External Id：MCF7_OneDose

实验名称：Inhibition of recombinant human carbonic anhydrase-1 incubated for 15 mins by stopped... 来源：ChEMBL 靶标：Carbonic anhydrase 1 External Id：CHEMBL4316148

实验名称：NCI human tumor cell line growth inhibition assay. Data for the IGROV1 Non-Small Cell... 来源：DTP/NCI 靶标：N/A External Id：IGROV1_OneDose

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