HCAIX-IN-1

• 常用名: HCAIX-IN-1
• 英文名: HCAIX-IN-1
• CAS号: 2389034-65-3
• 分子量: 403.42
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₆H₁₇N₇O₄S
• 熔点: N/A
• 闪点: N/A

HCAIX-IN-1用途

HCAIX-IN-1(化合物21e)是一种有效且选择性的HCAIX抑制剂,其对hCA I、hCA II、hCA IX、hCA XII的KI分别为694.9、126.6、3.3、9.8nM[1]。

HCAIX-IN-1名称

• 英文名: HCAIX-IN-1

HCAIX-IN-1生物活性

• 描述: HCAIX-IN-1(化合物21e)是一种有效且选择性的HCAIX抑制剂,其对hCA I、hCA II、hCA IX、hCA XII的KI分别为694.9、126.6、3.3、9.8nM[1]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 代谢酶/蛋白酶 >> 碳酸酐酶
• 靶点实验:

  hCA I:694.9 nM (Ki)

  hCA II:126.6 nM (Ki)

  hCA IX:3.3 nM (Ki)

  hCA XII:9.8 nM (Ki)

• 参考文献:

  [1]. Said MA,et al. Synthesis, biological and molecular dynamics investigations with a series of triazolopyrimidine/triazole-based benzenesulfonamides as novel carbonic anhydrase inhibitors. Eur J Med Chem. 2020 Jan 1;185:111843.

HCAIX-IN-1物理化学性质

• 分子式: C₁₆H₁₇N₇O₄S
• 分子量: 403.42
• InChIKey: LSVDQIASEPSKLW-UHFFFAOYSA-N
• SMILES: COc1ccc(NC(=O)Nc2nc(N)n(-c3ccc(S(N)(=O)=O)cc3)n2)cc1

HCAIX-IN-1靶点实验

查看更多实验

实验名称：Inhibition of recombinant human carbonic anhydrase-2 at 10 uM after 15 mins by stoppe... 来源：ChEMBL 靶标：Carbonic anhydrase 2 External Id：CHEMBL4316172

实验名称：Inhibition of recombinant human carbonic anhydrase-12 at 1 uM after 15 mins by stoppe... 来源：ChEMBL 靶标：Carbonic anhydrase 12 External Id：CHEMBL4316171

实验名称：Inhibition of recombinant human carbonic anhydrase-12 at 0.1 uM after 15 mins by stop... 来源：ChEMBL 靶标：Carbonic anhydrase 12 External Id：CHEMBL4316170

实验名称：Inhibition of recombinant human carbonic anhydrase-12 at 0.01 uM after 15 mins by sto... 来源：ChEMBL 靶标：Carbonic anhydrase 12 External Id：CHEMBL4316169

实验名称：Inhibition of recombinant human carbonic anhydrase-12 at 1 nM after 15 mins by stoppe... 来源：ChEMBL 靶标：Carbonic anhydrase 12 External Id：CHEMBL4316168

实验名称：Inhibition of recombinant human carbonic anhydrase-9 at 0.1 uM after 15 mins by stopp... 来源：ChEMBL 靶标：Carbonic anhydrase 9 External Id：CHEMBL4316166

实验名称：Inhibition of recombinant human carbonic anhydrase-9 at 0.01 uM after 15 mins by stop... 来源：ChEMBL 靶标：Carbonic anhydrase 9 External Id：CHEMBL4316165

实验名称：Inhibition of recombinant human carbonic anhydrase-9 at 0.1 nM after 15 mins by stopp... 来源：ChEMBL 靶标：Carbonic anhydrase 9 External Id：CHEMBL4316173

实验名称：Inhibition of recombinant human carbonic anhydrase-1 at 0.01 uM after 15 mins by stop... 来源：ChEMBL 靶标：Carbonic anhydrase 1 External Id：CHEMBL4316156

实验名称：Selectivity index, ratio of Ki for recombinant human carbonic anhydrase-2 to Ki for r... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4316155

共26条，当前第1页，共3页

1

2

3