PAK4-IN-1

• 常用名: PAK4-IN-1
• 英文名: PAK4-IN-1
• CAS号: 2396529-58-9
• 分子量: 556.01
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₆H₃₀ClN₇O₅
• 熔点: N/A
• 闪点: N/A

PAK4-IN-1用途

PAK4-IN-1(化合物19)是一种高效、选择性、口服活性PAK4抑制剂,在体内具有强大的抗肿瘤功效。PAK4-IN-1在酸性和中性条件下都是稳定的【1】。

PAK4-IN-1名称

• 英文名: PAK4-IN-1

PAK4-IN-1生物活性

• 描述: PAK4-IN-1(化合物19)是一种高效、选择性、口服活性PAK4抑制剂,在体内具有强大的抗肿瘤功效。PAK4-IN-1在酸性和中性条件下都是稳定的【1】。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 细胞骨架 >> PAK
  信号通路 >> 细胞周期/DNA损伤 >> PAK
• 靶点实验:

  PAK4

• 参考文献:

  [1]. Jing Guo, et al. Synthesis, bioconversion, pharmacokinetic and pharmacodynamic evaluation of N-isopropyl-oxy-carbonyloxymethyl prodrugs of CZh-226, a potent and selective PAK4 inhibitor. Eur J Med Chem. 2020 Jan 15;186:111878.

PAK4-IN-1物理化学性质

• 分子式: C₂₆H₃₀ClN₇O₅
• 分子量: 556.01

PAK4-IN-1靶点实验

查看更多实验

实验名称：Half life in Wistar rat assessed as (R)-(6-chloro-4-(5-cyclopropyl-1H-pyrazol-3-ylami... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4767488

实验名称：Tmax in Wistar rat assessed as (R)-(6-chloro-4-(5-cyclopropyl-1H-pyrazol-3-ylamino)qu... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4767489

实验名称：AUC in Wistar rat assessed as (R)-(6-chloro-4-(5-cyclopropyl-1H-pyrazol-3-ylamino)qui... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4767486

实验名称：AUC (0 to infinity) in Wistar rat assessed as (R)-(6-chloro-4-(5-cyclopropyl-1H-pyraz... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4767487

实验名称：Clearance in Wistar rat assessed as (R)-(6-chloro-4-(5-cyclopropyl-1H-pyrazol-3-ylami... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4767474

实验名称：Initial plasma concentration in Wistar rat assessed as (R)-(6-chloro-4-(5-cyclopropyl... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4767475

实验名称：Stability of the compound in rat liver S9 fraction assessed as compound remaining mea... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4767472

实验名称：Prodrug conversion in rat liver S9 fraction assessed as release of active metabolite ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4767473

实验名称：Inhibition of recombinant human PAK4 kinase domain (300 to 591 residues) expressed in... 来源：ChEMBL 靶标：Serine/threonine-protein kinase PAK 4 External Id：CHEMBL4767466

实验名称：Chemical stability of the compound in pH 7.4 PBS buffer assessed as compound remainin... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4767467

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