QX-314 bromide

• 常用名: QX-314 bromide
• 英文名: QX 314 bromide
• CAS号: 24003-58-5
• 分子量: 343.30200
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₆H₂₇BrN₂O
• 熔点: N/A
• 闪点: N/A

QX-314 bromide用途

QX-314 bromide 是一种膜不渗透的钠离子通道永久性电荷阻滞剂。

QX-314 bromide名称

• 中文名: QX-314 (bromide)
• 英文名: QX-314 (bromide)

QX-314 bromide生物活性

• 描述: QX-314 bromide 是一种膜不渗透的钠离子通道永久性电荷阻滞剂。
• 相关类别:
  信号通路 >> 跨膜转运 >> 钠通道
  研究领域 >> 神经疾病
• 靶点实验:

  sodium channel[1]

• 体外研究: QX-314溴化物在体外对瞬时受体电位香草醛1型通道(TRPV1)具有双相作用[1]。QX-314溴化物(1–60 mM)以浓度依赖的方式直接激活TRPV1[1]。溴化QX-314(≥30mm)引起卵母细胞膜变黑和细胞死亡[1]。QX-314溴化物抑制海马CA1锥体神经元胞内钙电流,低阈值(T型)Ca2+电流平均小于控制幅度的10%。由于细胞内Br-[3]的存在,QX-314溴化物使电流-电压关系(I-Vs)向正电压方向移动。
• 体内研究: QX-314溴化物(1.6毫克/公斤；I.C)取消对有害的机械和热刺激的反应,而没有与辣椒素(2)联合治疗时的运动或触觉缺陷。动物模型：Male Sprague Dawley大鼠(250- 290g)[ 2 ]剂量：1.6 mg/kg给药：皮内注射结果：取消与有害的机械和热刺激的反应,而没有与辣椒素联合治疗时的运动或触觉缺陷。
• 参考文献:

  [1]. Rivera-Acevedo RE, et al. The quaternary lidocaine derivative, QX-314, exerts biphasic effects on transient receptor potential vanilloid subtype 1 channels in vitro. Anesthesiology. 2011 Jun;114(6):1425-34.

  [2]. Binshtok AM, et al. Coapplication of lidocaine and the permanently charged sodium channel blocker QX-314 produces a long-lasting nociceptive blockade in rodents. Anesthesiology. 2009 Jul;111(1):127-37.

  [3]. Talbot MJ, et al. Intracellular QX-314 inhibits calcium currents in hippocampal CA1 pyramidal neurons. J Neurophysiol. 1996 Sep;76(3):2120-4.

QX-314 bromide物理化学性质

• 分子式: C₁₆H₂₇BrN₂O
• 分子量: 343.30200
• 精确质量: 342.13100
• PSA: 29.10000
• LogP: 0.19540
• InChIKey: DLHMKHREUTXMCH-UHFFFAOYSA-N
• SMILES: CC[N+](CC)(CC)CC(=O)Nc1c(C)cccc1C.[Br-]
• 储存条件: -20°C，密闭，干燥

QX-314 bromide靶点实验

查看更多实验

实验名称：Primary cell-based high-throughput screening assay for identification of compounds th... 来源：Johns Hopkins Ion Channel Center 靶标：regulator of G-protein signaling 4 isoform 2 [Homo sapiens] External Id：JHICC_RGS_Act_HTS

实验名称：Luminescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：mu-type opioid receptor isoform MOR-1 [Homo sapiens] External Id：OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN

实验名称：QFRET-based biochemical primary high throughput screening assay to identify exosite i... 来源：The Scripps Research Institute Molecular Screening Center 靶标：disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] External Id：ADAM17_INH_QFRET_1536_1X%INH PRUN

实验名称：Inhibition of neurosphere proliferation of mouse neural precursor cells by MTT assay 来源：ChEMBL 靶标：N/A External Id：CHEMBL1266185

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

实验名称：uHTS identification of small molecule activators of the adaptive arm of the Unfolded ... 来源：Burnham Center for Chemical Genomics 靶标：N/A External Id：BCCG-A405-UPR-XBP1-PrimaryAgonist-Assay

实验名称：Rescue cell viability in cybrid cells with a genetic mutation in complex 1 of the mit... 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：N/A External Id：HMS1315

实验名称：Fluorescence polarization to screen for inhibitor that competite the binding of FadD2... 来源：Broad Institute 靶标：FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE) External Id：2147-01_Inhibitor_SinglePoint_HTS_Activity

实验名称：Tocris HTS for Inhibitors of Aerobactin Synthetase lucA 来源：23265 External Id：IucA Pilot Assay Tocris Library

实验名称：Dicer-mediated maturation of pre-microRNA 来源：Center for Chemical Genomics, University of Michigan 靶标：N/A External Id：TargetID_659_CEMA

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QX-314 bromide英文别名

• Hepato-Scan
• Lidofenin
• 2,6-dimethylacetanilideiminodiacetic acid
• Ellipticine
• Lidocaine N-ethyl bromide
• Hida