QX 314 bromide

Modify Date: 2024-01-14 19:26:28

QX 314 bromide structure	Common Name	QX 314 bromide
	CAS Number	24003-58-5	Molecular Weight	343.30200
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₆H₂₇BrN₂O	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of QX 314 bromide

QX-314 bromide is a membrane-impermeable permanently charged sodium channel blocker[1].

Name	QX-314 (bromide)
Synonym	More Synonyms

Description	QX-314 bromide is a membrane-impermeable permanently charged sodium channel blocker[1].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel Research Areas >> Neurological Disease
Target	sodium channel[1]
In Vitro	QX-314 bromide exerts biphasic effects on transient receptor potential vanilloid subtype 1 channels (TRPV1) in vitro [1]. QX-314 bromide (1–60 mM) directly activates TRPV1 in a concentration-dependent manner[1]. QX-314 bromide (≥ 30 mM) produces oocyte membrane blackening and cell death [1]. QX-314 bromide inhibits calcium currents in hippocampal CA1 pyramidal neurons intracellular, and the low-threshold (T-type) Ca2+ currents are on average < 10% of control amplitude [3]. QX-314 bromide shifts the current-voltage relationships (I-Vs) in the positive voltage direction due to the presence of intracellular Br- [3].
In Vivo	QX-314 bromide (1.6 mg/kg; i.c.) abolishes responses to noxious mechanical and thermal stimuli without motor or tactile deficits when co-treatment with capsaicin[2]. Animal Model: Male Sprague-Dawley rats (250-290 g)[2] Dosage: 1.6 mg/kg Administration: Intracutaneous injection Result: Abolished responses to noxious mechanical and thermal stimuli without motor or tactile deficits when co-treatment with capsaicin.
References	[1]. Rivera-Acevedo RE, et al. The quaternary lidocaine derivative, QX-314, exerts biphasic effects on transient receptor potential vanilloid subtype 1 channels in vitro. Anesthesiology. 2011 Jun;114(6):1425-34. [2]. Binshtok AM, et al. Coapplication of lidocaine and the permanently charged sodium channel blocker QX-314 produces a long-lasting nociceptive blockade in rodents. Anesthesiology. 2009 Jul;111(1):127-37. [3]. Talbot MJ, et al. Intracellular QX-314 inhibits calcium currents in hippocampal CA1 pyramidal neurons. J Neurophysiol. 1996 Sep;76(3):2120-4.

Molecular Formula	C₁₆H₂₇BrN₂O
Molecular Weight	343.30200
Exact Mass	342.13100
PSA	29.10000
LogP	0.19540

Bromoethane structure

Bromoethane

CAS#:74-96-4

Lidocaine structure

Lidocaine

CAS#:137-58-6

~%

QX 314 bromide Structure

QX 314 bromide

CAS#:24003-58-5

Literature: Loefgren; Fischer Svensk Kemisk Tidskrift, 1946 , vol. 58, p. 219,229

Precursor 2
CAS#:74-96-4 Bromoethane CAS#:137-58-6 Lidocaine
DownStream 0

Hepato-Scan

Lidofenin

2,6-dimethylacetanilideiminodiacetic acid

Ellipticine

Lidocaine N-ethyl bromide

Hida

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: QX-314 (bromide)
Price: Negotiable
Purity: 98.0%
Delivery: 10 Day
Contact: Huang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: QX-314 bromide
Price: $Inquiry/1g
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

ShangHai DC Chemicals Co.,Ltd
China
Product Name: QX-314 bromide
Price: ￥Inquiry/1g
Purity: 98.9%
Delivery: 1 Day
Contact: Tony Lai
Email: order@dcchemicals.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: N-ETHYLLIDOCAINE BROMIDE
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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