DPP-4 inhibitor 3

• 常用名: DPP-4 inhibitor 3
• 英文名: DPP-4 inhibitor 3
• CAS号: 2402735-14-0
• 分子量: 366.42
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₉H₂₂N₆O₂
• 熔点: N/A
• 闪点: N/A

DPP-4 inhibitor 3用途

DPP-4抑制剂3(化合物5a)是一种有效的二肽基肽酶IV(DPP-IV)抑制剂,IC50为0.75 nM。DPP-4抑制剂3显示出优异的抗氧化和促胰岛素活性[1]。

DPP-4 inhibitor 3名称

• 英文名: DPP-4 inhibitor 3

DPP-4 inhibitor 3生物活性

• 描述: DPP-4抑制剂3(化合物5a)是一种有效的二肽基肽酶IV(DPP-IV)抑制剂,IC50为0.75 nM。DPP-4抑制剂3显示出优异的抗氧化和促胰岛素活性[1]。
• 相关类别:
  信号通路 >> 代谢酶/蛋白酶 >> 二肽基肽酶
  信号通路 >> 蛋白酪氨酸激酶 >> ROS
  研究领域 >> 代谢疾病
• 靶点实验:

  IC50: 0.75 nM (DPP-IV)[1]

• 参考文献:

  [1]. Bindu B, et al. Synthesis and discovery of triazolo-pyridazine-6-yl-substituted piperazines as effective anti-diabetic drugs; evaluated over dipeptidyl peptidase-4 inhibition mechanism and insulinotropic activities. Eur J Med Chem. 2020 Feb 1;187:111912.

DPP-4 inhibitor 3物理化学性质

• 分子式: C₁₉H₂₂N₆O₂
• 分子量: 366.42

DPP-4 inhibitor 3靶点实验

查看更多实验

实验名称：Inhibition of human DPP4 来源：ChEMBL 靶标：Dipeptidyl peptidase 4 External Id：CHEMBL4379981

实验名称：Inhibition of human DPP4 in pH 7.4 Tris buffer using AP-7-ATFMC as substrate preincub... 来源：ChEMBL 靶标：Dipeptidyl peptidase 4 External Id：CHEMBL4379982

实验名称：Inhibition of human DPP4 in pH 7.4 Tris buffer using AP-7-ATFMC as substrate preincub... 来源：ChEMBL 靶标：Dipeptidyl peptidase 4 External Id：CHEMBL4379983

实验名称：Antioxidant activity assessed as inhibition of H2O2 radical scavenging activity incub... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4379984

实验名称：Antioxidant activity assessed as inhibition of H2O2 radical scavenging activity incub... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4379985

实验名称：Cytotoxicity against rat INS1(832/13) cells assessed as cell viability upto 3 nM in R... 来源：ChEMBL 靶标：INS1(832/13) External Id：CHEMBL4379986

实验名称：Antidiabetic activity in glucose-treated rat INS1(832/13) cells assessed as increase ... 来源：ChEMBL 靶标：INS1(832/13) External Id：CHEMBL4379987

实验名称：Antidiabetic activity in glucose-treated rat INS1(832/13) cells assessed as increase ... 来源：ChEMBL 靶标：INS1(832/13) External Id：CHEMBL4379988

实验名称：Antidiabetic activity in glucose-treated rat INS1(832/13) cells assessed as increase ... 来源：ChEMBL 靶标：INS1(832/13) External Id：CHEMBL4379990

实验名称：Cytotoxicity against rat INS1(832/13) cells assessed as cell viability at 3.5 nM in R... 来源：ChEMBL 靶标：INS1(832/13) External Id：CHEMBL4379980

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