COX-2/5-LOX-IN-1

• 常用名: COX-2/5-LOX-IN-1
• 英文名: COX-2/5-LOX-IN-1
• CAS号: 2410384-50-6
• 分子量: 383.83
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₄H₁₀ClN₃O₄S₂
• 熔点: N/A
• 闪点: N/A

COX-2/5-LOX-IN-1用途

COX-2/5-LOX-IN-1(化合物3a)是一种有效的COX-2/5-LOX双重抑制剂。COX-2/5-LOX-IN-1是苯并噻吩-2-基吡唑羧酸衍生物。COX-2/5-LOX-IN-1的镇痛和抗炎活性超过塞来昔布和吲哚美辛。COX-2/5-LOX-IN-1显示出较强的COX-1、COX-2和5-LOX抑制活性,IC50分别为12.13、0.4和4.96μM【1】。

COX-2/5-LOX-IN-1名称

• 英文名: COX-2/5-LOX-IN-1

COX-2/5-LOX-IN-1生物活性

• 描述: COX-2/5-LOX-IN-1(化合物3a)是一种有效的COX-2/5-LOX双重抑制剂。COX-2/5-LOX-IN-1是苯并噻吩-2-基吡唑羧酸衍生物。COX-2/5-LOX-IN-1的镇痛和抗炎活性超过塞来昔布和吲哚美辛。COX-2/5-LOX-IN-1显示出较强的COX-1、COX-2和5-LOX抑制活性,IC50分别为12.13、0.4和4.96μM【1】。
• 相关类别:
  研究领域 >> 炎症/免疫
  信号通路 >> 免疫及炎症 >> COX
• 参考文献:

  [1]. Gedawy EM, et al. Design, synthesis and biological evaluation of novel pyrazole sulfonamide derivatives as dual COX-2/5-LOX inhibitors. Eur J Med Chem. 2020;189:112066.

COX-2/5-LOX-IN-1物理化学性质

• 分子式: C₁₄H₁₀ClN₃O₄S₂
• 分子量: 383.83
• InChIKey: MBYVVQGJJDBRKH-UHFFFAOYSA-N
• SMILES: NS(=O)(=O)c1ccc(-n2nc(C(=O)O)cc2-c2ccc(Cl)s2)cc1

COX-2/5-LOX-IN-1靶点实验

查看更多实验

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实验名称：Antiinflammatory activity in Wistar albino rat assessed as protection against carrage... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL4684637

实验名称：Antiinflammatory activity in Wistar albino rat assessed as reduction in carrageenan-i... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL4684636

实验名称：Antiinflammatory activity in Wistar albino rat assessed as protection against carrage... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL4684639

实验名称：Antiinflammatory activity in Wistar albino rat assessed as reduction in carrageenan-i... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL4684638

实验名称：Antiinflammatory activity in Wistar albino rat assessed as protection against carrage... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL4684641

实验名称：Antiinflammatory activity in Wistar albino rat assessed as reduction in carrageenan-i... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL4684640

实验名称：Analgesic activity in albino mouse assessed as protection against acetic acid-induced... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL4684631

实验名称：Analgesic activity in albino mouse assessed as reduction in acetic acid-induced numbe... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL4684633

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