Carbonic anhydrase inhibitor 14

• 常用名: Carbonic anhydrase inhibitor 14
• 英文名: Carbonic anhydrase inhibitor 14
• CAS号: 2410402-75-2
• 分子量: 395.44
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₈H₁₇N₇O₂S
• 熔点: N/A
• 闪点: N/A

Carbonic anhydrase inhibitor 14用途

碳酸酐酶抑制剂14(化合物8b)是一种碳酸酐酶(CA)抑制剂,其Ki值分别为1203、99.7、9.4和27.7nM,分别针对hCA I、hCA II、hCA IX和hCA XII。碳酸酐酶抑制剂14也可以抑制CDK2,IC50为20.3μM。碳酸酐酶抑制剂14具有抗肿瘤活性[1]。

Carbonic anhydrase inhibitor 14名称

• 英文名: Carbonic anhydrase inhibitor 14

Carbonic anhydrase inhibitor 14生物活性

• 描述: 碳酸酐酶抑制剂14(化合物8b)是一种碳酸酐酶(CA)抑制剂,其Ki值分别为1203、99.7、9.4和27.7nM,分别针对hCA I、hCA II、hCA IX和hCA XII。碳酸酐酶抑制剂14也可以抑制CDK2,IC50为20.3μM。碳酸酐酶抑制剂14具有抗肿瘤活性[1]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 代谢酶/蛋白酶 >> 碳酸酐酶
  信号通路 >> 细胞周期/DNA损伤 >> CDK
• 靶点实验:

  CDK2:20.3 μM (IC50)

  hCA I:1203 nM (Ki)

  hCA II:99.7 nM (Ki)

  hCA IX:9.4 nM (Ki)

  hCA XII:27.7 nM (Ki)

• 参考文献:

  [1]. Said MA, et al. Sulfonamide-based ring-fused analogues for CAN508 as novel carbonic anhydrase inhibitors endowed with antitumor activity: Design, synthesis, and in vitro biological evaluation. Eur J Med Chem. 2020 Mar 1;189:112019.

Carbonic anhydrase inhibitor 14物理化学性质

• 分子式: C₁₈H₁₇N₇O₂S
• 分子量: 395.44

Carbonic anhydrase inhibitor 14靶点实验

查看更多实验

实验名称：Antitumor activity against human NCI/ADR-RES cells assessed as cell growth inhibition... 来源：ChEMBL 靶标：NCI/ADR-RES External Id：CHEMBL4684492

实验名称：Inhibition of recombinant human carbonic anhydrase 9 preincubated with enzyme for 15 ... 来源：ChEMBL 靶标：Carbonic anhydrase 9 External Id：CHEMBL4684411

实验名称：Inhibition of recombinant human carbonic anhydrase 2 preincubated with enzyme for 15 ... 来源：ChEMBL 靶标：Carbonic anhydrase 2 External Id：CHEMBL4684410

实验名称：Selectivity index, ratio of Ki for recombinant human carbonic anhydrase 1 preincubate... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4684413

实验名称：Inhibition of recombinant human carbonic anhydrase 12 preincubated with enzyme for 15... 来源：ChEMBL 靶标：Carbonic anhydrase 12 External Id：CHEMBL4684412

实验名称：Selectivity index, ratio of Ki for recombinant human carbonic anhydrase 2 preincubate... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4684415

实验名称：Selectivity index, ratio of Ki for recombinant human carbonic anhydrase 1 preincubate... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4684414

实验名称：Inhibition of CDK2/cyclin E (unknown origin) expressed in baculovirus infected Sf21 i... 来源：ChEMBL 靶标：G1/S-specific cyclin-E1 External Id：CHEMBL4684417

实验名称：Selectivity index, ratio of Ki for recombinant human carbonic anhydrase 2 preincubate... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4684416

实验名称：Inhibition of recombinant human carbonic anhydrase 1 preincubated with enzyme for 15 ... 来源：ChEMBL 靶标：Carbonic anhydrase 1 External Id：CHEMBL4684409

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