5-HT6/5-HT2A receptor ligand-2

• 常用名: 5-HT6/5-HT2A receptor ligand-2
• 英文名: 5-HT6/5-HT2A receptor ligand-2
• CAS号: 2411088-16-7
• 分子量: 351.37
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₀H₁₈FN₃O₂
• 熔点: N/A
• 闪点: N/A

5-HT6/5-HT2A receptor ligand-2用途

5-HT6/5-HT2A受体配体-2(化合物42)是一种脑渗透剂双5-HT6/5-HT2A受体拮抗剂,Ki为25 nM 32 分别为nM。5-HT6/5-HT2A受体配体-2具有促认知特性[1]。

5-HT6/5-HT2A receptor ligand-2名称

• 英文名: 5-HT6/5-HT2A receptor ligand-2

5-HT6/5-HT2A receptor ligand-2生物活性

• 描述: 5-HT6/5-HT2A受体配体-2(化合物42)是一种脑渗透剂双5-HT6/5-HT2A受体拮抗剂,Ki为25 nM 32 分别为nM。5-HT6/5-HT2A受体配体-2具有促认知特性[1]。
• 相关类别:
  研究领域 >> 神经疾病
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 5-HT受体
  信号通路 >> 神经信号通路 >> 5-HT受体
• 靶点实验:

  5-HT6 Receptor:25 nM (Ki)

  5-HT2A Receptor:32 nM (Ki)

• 参考文献:

  [1]. Staroń J, et, al. Virtual screening-driven discovery of dual 5-HT 6/5-HT 2A receptor ligands with pro-cognitive properties. Eur J Med Chem. 2020 Jan 1;185:111857.

5-HT6/5-HT2A receptor ligand-2物理化学性质

• 分子式: C₂₀H₁₈FN₃O₂
• 分子量: 351.37

5-HT6/5-HT2A receptor ligand-2靶点实验

查看更多实验

实验名称：Substrate activity at Pgp (unknown origin) assessed as permeability from apical to ba... 来源：ChEMBL 靶标：ATP-dependent translocase ABCB1 External Id：CHEMBL4316428

实验名称：Inhibition of human ERG at 10'-6 M relative to control 来源：ChEMBL 靶标：Potassium voltage-gated channel subfamily H member 2 External Id：CHEMBL4316427

实验名称：Antagonist activity at 5-HT2CR (unknown origin) at 10'-6 M relative to control 来源：ChEMBL 靶标：5-hydroxytryptamine receptor 2C External Id：CHEMBL4316426

实验名称：Displacement of [3H]pyrilamine from recombinant human M1 receptor at 10'-6 M after 60... 来源：ChEMBL 靶标：Muscarinic acetylcholine receptor M1 External Id：CHEMBL4316425

实验名称：Displacement of [3H]pyrilamine from recombinant human H1 receptor at 10'-6 M after 60... 来源：ChEMBL 靶标：Histamine H1 receptor External Id：CHEMBL4316424

实验名称：Displacement of [3H]prazosin from recombinant human alpha 1A adreno receptor at 10'-6... 来源：ChEMBL 靶标：Alpha-1A adrenergic receptor External Id：CHEMBL4316423

实验名称：Displacement of [3H]-Ketanserin from recombinant human 5-HT2A receptor at 10'-7 M aft... 来源：ChEMBL 靶标：5-hydroxytryptamine receptor 2A External Id：CHEMBL4316422

实验名称：Displacement of [3H]-Ketanserin from recombinant human 5-HT2A receptor at 10'-6 M aft... 来源：ChEMBL 靶标：5-hydroxytryptamine receptor 2A External Id：CHEMBL4316421

实验名称：Reversal of phencyclidine-induced memory impairment in Sprague-Dawley rat at 3 to 10 ... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL4316436

实验名称：Ratio of Cmax in brain to plasma in Wistar rat at 10 mg/kg, po 来源：ChEMBL 靶标：N/A External Id：CHEMBL4316435

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