IACS-15414

• 常用名: IACS-15414
• 英文名: IACS-15414
• CAS号: 2411321-29-2
• 分子量: 423.34
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₀H₂₄Cl₂N₄O₂
• 熔点: N/A
• 闪点: N/A

IACS-15414用途

IACS-15414是一种有效的口服生物利用度SHP2抑制剂,IC50值为122 nM。

IACS-15414名称

• 英文名: IACS-15414

IACS-15414生物活性

• 描述: IACS-15414是一种有效的口服生物利用度SHP2抑制剂,IC50值为122 nM。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 代谢酶/蛋白酶 >> 磷酸酶
• 参考文献:

  [1]. Czako B, et al. Discovery of 6-[(3S,4S)-4-Amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl]-3-(2,3-dichlorophenyl)-2-methyl-3,4-dihydropyrimidin-4-one (IACS-15414), a Potent and Orally Bioavailable SHP2 Inhibitor. J Med Chem. 2021 Oct 28;64(20):15141-15169.

IACS-15414物理化学性质

• 分子式: C₂₀H₂₄Cl₂N₄O₂
• 分子量: 423.34
• InChIKey: WYUIJDCKOPRFJO-HXPMCKFVSA-N
• SMILES: Cc1nc(N2CCC3(CC2)COC(C)C3N)cc(=O)n1-c1cccc(Cl)c1Cl

IACS-15414靶点实验

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实验名称：In vivo inhibition of MAPK signaling pathway in po dosed mouse xenografted with human... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5098592

实验名称：Clearance in iv dosed CD-1 mouse measured at 0.083 to 24 hrs by LC-MS/MS analysis 来源：ChEMBL 靶标：N/A External Id：CHEMBL5098593

实验名称：Inhibition of N-terminal his6-tagged wild type recombinant human SHP2 (1 to 597 resid... 来源：ChEMBL 靶标：Tyrosine-protein phosphatase non-receptor type 11 External Id：CHEMBL5098594

实验名称：Clearance in iv dosed Cynomolgus monkey measured at 0.083 to 24 hrs by LC-MS/MS analy... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5098588

实验名称：Clearance in iv dosed Beagle dog measured at 0.083 to 24 hrs by LC-MS/MS analysis 来源：ChEMBL 靶标：N/A External Id：CHEMBL5098589

实验名称：Clearance in iv dosed Sprague-Dawley rat measured at 0.083 to 24 hrs by LC-MS/MS anal... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5098590

实验名称：Plasma protein binding in Beagle dog incubated for 5 hrs by LC-MS analysis 来源：ChEMBL 靶标：N/A External Id：CHEMBL5098623

实验名称：Plasma protein binding in monkey incubated for 5 hrs by LC-MS analysis 来源：ChEMBL 靶标：N/A External Id：CHEMBL5098624

实验名称：Metabolic stability in mouse microsome assessed as intrinsic clearance incubated for ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5098625

实验名称：Metabolic stability in Beagle dog microsome assessed as intrinsic clearance incubated... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5098626

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