Microtubule inhibitor 4

• 常用名: Microtubule inhibitor 4
• 英文名: Microtubule inhibitor 4
• CAS号: 2411962-64-4
• 分子量: 446.47
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₅H₂₃FN₄O₃
• 熔点: N/A
• 闪点: N/A

Microtubule inhibitor 4用途

微管抑制剂4(化合物2)是一种有效的微管抑制剂。微管抑制剂4对NCI-H460、BxPC-3和HT-29细胞的IC50s分别为4.0、3.2和2.1 nM,显示出细胞毒性。微管抑制剂4显示对微管蛋白聚合的抑制[1]。

Microtubule inhibitor 4名称

• 英文名: Microtubule inhibitor 4

Microtubule inhibitor 4生物活性

• 描述: 微管抑制剂4(化合物2)是一种有效的微管抑制剂。微管抑制剂4对NCI-H460、BxPC-3和HT-29细胞的IC50s分别为4.0、3.2和2.1 nM,显示出细胞毒性。微管抑制剂4显示对微管蛋白聚合的抑制[1]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 细胞周期/DNA损伤 >> 微管/微管蛋白
  信号通路 >> 细胞骨架 >> 微管/微管蛋白
• 参考文献:

  [1]. Ding Z, et al. Structure-based design and synthesis of novel furan-diketopiperazine-type derivatives as potent microtubule inhibitors for treating cancer. Bioorg Med Chem. 2020 May 15;28(10):115435.

Microtubule inhibitor 4物理化学性质

• 分子式: C₂₅H₂₃FN₄O₃
• 分子量: 446.47

Microtubule inhibitor 4靶点实验

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实验名称：Inhibition of tubulin in human NCI-H460 cells assessed as inhibition of microtubule p... 来源：ChEMBL 靶标：Tubulin alpha-3C chain External Id：CHEMBL4629254

实验名称：Inhibition of tubulin polymerization in human NCI-H460 cells assessed as formation of... 来源：ChEMBL 靶标：Tubulin alpha-3C chain External Id：CHEMBL4614096

实验名称：Inhibition of porcine brain tubulin polymerization at 5 uM by fluorescence analysis r... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4614095

实验名称：Cytotoxicity against human NCI-H460 cells assessed as reduction in cell viability aft... 来源：ChEMBL 靶标：NCI-H460 External Id：CHEMBL4629251

实验名称：Antiproliferative activity against human NCI-H460 cells assessed as reduction in cell... 来源：ChEMBL 靶标：NCI-H460 External Id：CHEMBL4614090

实验名称：Cytotoxicity against human HT-29 cells assessed as reduction in cell viability after ... 来源：ChEMBL 靶标：HT-29 External Id：CHEMBL4629253

实验名称：Cytotoxicity against human BxPC3 cells assessed as reduction in cell viability incuba... 来源：ChEMBL 靶标：BXPC-3 External Id：CHEMBL4629252

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