Mt KARI-IN-2

• 常用名: Mt KARI-IN-2
• 英文名: Mt KARI-IN-2
• CAS号: 2413974-52-2
• 分子量: 377.40
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₄H₁₁N₅O₄S₂
• 熔点: N/A
• 闪点: N/A

Mt KARI-IN-2用途

Mt-KARI-IN-2(化合物5b)是一种有效的结核分枝杆菌酮酸还原异构酶(Mtb-KARI)抑制剂,Ki值为2.02μM。Mt-KARI-IN-2对Mtb H37Rv具有抑制活性(MIC=0.78μM)和低细胞毒性(HEK IC50>86μg/mL)[1]。

Mt KARI-IN-2名称

• 英文名: Mt KARI-IN-2

Mt KARI-IN-2生物活性

• 描述: Mt-KARI-IN-2(化合物5b)是一种有效的结核分枝杆菌酮酸还原异构酶(Mtb-KARI)抑制剂,Ki值为2.02μM。Mt-KARI-IN-2对Mtb H37Rv具有抑制活性(MIC=0.78μM)和低细胞毒性(HEK IC50>86μg/mL)[1]。
• 相关类别:
  研究领域 >> 感染
  信号通路 >> 抗感染 >> 细菌
• 靶点实验:

  Ki: 2.02 μM (Mtb KARI)[1]

• 参考文献:

  [1]. Krishna VS, et al. Design and development of ((4-methoxyphenyl)carbamoyl) (5-(5-nitrothiophen-2-yl)-1,3,4-thiadiazol-2-yl)amide analogues as Mycobacterium tuberculosis ketol-acid reductoisomerase inhibitors. Eur J Med Chem. 2020;193:112178.

Mt KARI-IN-2物理化学性质

• 分子式: C₁₄H₁₁N₅O₄S₂
• 分子量: 377.40

Mt KARI-IN-2靶点实验

查看更多实验

实验名称：Antimycobacterial activity against dormant Mycobacterium tuberculosis H37Rv under nut... 来源：ChEMBL 靶标：Mycobacterium tuberculosis External Id：CHEMBL4686043

实验名称：Antimycobacterial activity against dormant Mycobacterium tuberculosis H37Rv incubated... 来源：ChEMBL 靶标：Mycobacterium tuberculosis External Id：CHEMBL4686042

实验名称：Inhibition of N-terminal 6His-taggged Mycobacterium tuberculosis KARI expressed in Es... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4686031

实验名称：Antitubercular activity against Mycobacterium tuberculosis H37Rv measured after 1 wee... 来源：ChEMBL 靶标：Mycobacterium tuberculosis External Id：CHEMBL4686033

实验名称：Inhibition of N-terminal 6His-taggged Mycobacterium tuberculosis KARI expressed in Es... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4686032

实验名称：Cytotoxicity against HEK293 cells assessed as reduction in cell viability measured af... 来源：ChEMBL 靶标：HEK293 External Id：CHEMBL4686035

实验名称：Antitubercular activity against isoniazid-resistant Mycobacterium tuberculosis clinic... 来源：ChEMBL 靶标：Mycobacterium tuberculosis External Id：CHEMBL4686034

实验名称：Antitubercular activity against Mycobacterium tuberculosis H37Rv infected in mouse pr... 来源：ChEMBL 靶标：Mycobacterium tuberculosis External Id：CHEMBL4686037

实验名称：Protection index, ratio IC50 for HEK293 cells to MIC for antitubercular activity agai... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4686036

实验名称：Antibiofilm activity against Mycobacterium tuberculosis assessed as log reduction in ... 来源：ChEMBL 靶标：Mycobacterium tuberculosis External Id：CHEMBL4686039

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