Zorevunersen

• 常用名: Zorevunersen
• 英文名: Zorevunersen
• CAS号: 2415330-04-8
• 分子量: 6682.39
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₀₄H₂₆₃N₆₃O₁₁₄P₂₀S₂₀
• 熔点: N/A
• 闪点: N/A

Zorevunersen用途

Zorevunersen(STK-001)是一种反义寡核苷酸,旨在提高SCN1A mRNA的产量,从而提高钠通道Nav1.1蛋白的表达。Zorevunersen用于Dravet综合征的研究。

Zorevunersen名称

• 英文名: Zorevunersen

Zorevunersen生物活性

• 描述: Zorevunersen(STK-001)是一种反义寡核苷酸,旨在提高SCN1A mRNA的产量,从而提高钠通道Nav1.1蛋白的表达。Zorevunersen用于Dravet综合征的研究。
• 相关类别:
  信号通路 >> 跨膜转运 >> 钠通道
  研究领域 >> 其他
• 靶点:

  Nav1.1

• 参考文献:

  [1]. Wengert ER, Wagley PK, Strohm SM, et al. Targeted Augmentation of Nuclear Gene Output (TANGO) of Scn1a rescues parvalbumin interneuron excitability and reduces seizures in a mouse model of Dravet Syndrome. Brain Res. 2022;1775:147743.

  [2]. Bialer M, Johannessen SI, Koepp MJ, et al. Progress report on new antiepileptic drugs: A summary of the Sixteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XVI): II. Drugs in more advanced clinical development. Epilepsia. 2022;63(11):2883-2910.

Zorevunersen物理化学性质

• 分子式: C₂₀₄H₂₆₃N₆₃O₁₁₄P₂₀S₂₀
• 分子量: 6682.39