IHCH-3064

• 常用名: IHCH-3064
• 英文名: IHCH-3064
• CAS号: 2420562-65-6
• 分子量: 479.49
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₅H₂₁N₉O₂
• 熔点: N/A
• 闪点: N/A

IHCH-3064用途

IHCH-3064是一种靶向腺苷A2A受体和HDAC的双作用化合物。IHCH-3064对A2AR(Ki=2.2nm)有强结合作用,对HDAC1有选择性抑制作用(IC50=80.2nm),体外对肿瘤细胞系有良好的抗增殖活性。IHCH-3064是一种肿瘤免疫治疗剂[1]。

IHCH-3064名称

• 英文名: IHCH-3064

IHCH-3064生物活性

• 描述: IHCH-3064是一种靶向腺苷A2A受体和HDAC的双作用化合物。IHCH-3064对A2AR(Ki=2.2nm)有强结合作用,对HDAC1有选择性抑制作用(IC50=80.2nm),体外对肿瘤细胞系有良好的抗增殖活性。IHCH-3064是一种肿瘤免疫治疗剂[1]。
• 相关类别:
  研究领域 >> 癌症
  研究领域 >> 炎症/免疫
  信号通路 >> 细胞周期/DNA损伤 >> HDAC
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 腺苷受体
  信号通路 >> 表观遗传学 >> HDAC
• 参考文献:

  [1]. Wenzhong Yan, et al. Structure-Based Design of Dual-Acting Compounds Targeting Adenosine A 2A Receptor and Histone Deacetylase as Novel Tumor Immunotherapeutic Agents. J Med Chem. 2021 Nov 25;64(22):16573-16597.

IHCH-3064物理化学性质

• 分子式: C₂₅H₂₁N₉O₂
• 分子量: 479.49

IHCH-3064靶点实验

查看更多实验

实验名称：Inhibition of HDAC in mouse MC38 cells assessed as increase in acetyl-histone H3 meas... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5032302

实验名称：Inhibition of HDAC in mouse MC38 cells assessed as increase in acetyl-histone H4 meas... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5032301

实验名称：Antitumour activity against mouse MC38 cells in C57BL/6 mouse assessed as tumour grow... 来源：ChEMBL 靶标：MC-38 External Id：CHEMBL5032300

实验名称：Antitumour activity against mouse MC38 cells in C57BL/6 mouse assessed as tumour grow... 来源：ChEMBL 靶标：MC-38 External Id：CHEMBL5032299

实验名称：Antitumour activity against mouse MC38 cells in C57BL/6 mouse assessed as tumour grow... 来源：ChEMBL 靶标：MC-38 External Id：CHEMBL5032298

实验名称：Inhibition of HDAC1 (unknown origin) assessed as release of 7-amino-4-methylcoumarin ... 来源：ChEMBL 靶标：Histone deacetylase 1 External Id：CHEMBL5032350

实验名称：Antiproliferative activity against mouse MC38 cells measured after 72 hrs by CCK8 ass... 来源：ChEMBL 靶标：MC-38 External Id：CHEMBL5032349

实验名称：Antiproliferative activity against mouse CT26 cells measured after 72 hrs by CCK8 ass... 来源：ChEMBL 靶标：CT26 External Id：CHEMBL5032348

实验名称：Elimination rate constant in ICR mouse at 20 mg/kg, po up to 24 hrs by LC-MS/MS analy... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5032347

实验名称：Toxicity in C57BL/6 mouse assessed as loss in body weight at 30 to 60 mg/kg, ip, bid ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5032353

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