Antitumor agent-57

• 常用名: Antitumor agent-57
• 英文名: Antitumor agent-57
• CAS号: 2432823-48-6
• 分子量: 349.34
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₀H₁₅NO₅
• 熔点: N/A
• 闪点: N/A

Antitumor agent-57用途

抗肿瘤剂-57(化合物3o)是一种NQO1定向抗肿瘤剂。抗肿瘤药物-57抑制肿瘤细胞生长,触发活性氧生成并诱导细胞凋亡[1]。

Antitumor agent-57名称

• 英文名: Antitumor agent-57

Antitumor agent-57生物活性

• 描述: 抗肿瘤剂-57(化合物3o)是一种NQO1定向抗肿瘤剂。抗肿瘤药物-57抑制肿瘤细胞生长,触发活性氧生成并诱导细胞凋亡[1]。
• 相关类别:
  信号通路 >> 细胞凋亡 >> 细胞凋亡
  研究领域 >> 癌症
  信号通路 >> 蛋白酪氨酸激酶 >> ROS
• 参考文献:

  [1]. Wu LQ, et al. Design, synthesis, and biological evaluation of 4-substituted-3,4-dihydrobenzo[h]quinoline-2,5,6(1H)-triones as NQO1-directed antitumor agents. Eur J Med Chem. 2020 Jul 15;198:112396.

Antitumor agent-57物理化学性质

• 分子式: C₂₀H₁₅NO₅
• 分子量: 349.34

Antitumor agent-57靶点实验

查看更多实验

实验名称：Induction of apoptosis in human HepG2 cells assessed as necrotic cells at 2.2 uM incu... 来源：ChEMBL 靶标：HepG2 External Id：CHEMBL4770690

实验名称：Induction of ROS generation in human HepG2 cells at 5 uM by DCFH-DA staining based fl... 来源：ChEMBL 靶标：HepG2 External Id：CHEMBL4770691

实验名称：Induction of apoptosis in human HepG2 cells assessed as early apoptotic cells at 2.2 ... 来源：ChEMBL 靶标：HepG2 External Id：CHEMBL4770688

实验名称：Induction of apoptosis in human HepG2 cells assessed as late apoptotic cells at 2.2 u... 来源：ChEMBL 靶标：HepG2 External Id：CHEMBL4770689

实验名称：Induction of mitochondrial membrane potential loss in human HepG2 cells at 4.4 uM inc... 来源：ChEMBL 靶标：HepG2 External Id：CHEMBL4770694

实验名称：Antitumor activity against human HepG2 cells xenografted in athymic nude mouse assess... 来源：ChEMBL 靶标：HepG2 External Id：CHEMBL4770695

实验名称：Induction of mitochondrial membrane potential loss in human HepG2 cells at 1.1 uM inc... 来源：ChEMBL 靶标：HepG2 External Id：CHEMBL4770692

实验名称：Induction of mitochondrial membrane potential loss in human HepG2 cells at 2.2 uM inc... 来源：ChEMBL 靶标：HepG2 External Id：CHEMBL4770693

实验名称：Induction of apoptosis in human HepG2 cells assessed as late apoptotic cells at 2.2 u... 来源：ChEMBL 靶标：HepG2 External Id：CHEMBL4770682

实验名称：Induction of apoptosis in human HepG2 cells assessed as necrotic cells at 2.2 uM incu... 来源：ChEMBL 靶标：HepG2 External Id：CHEMBL4770683

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