IL-17 modulator 4

• 常用名: IL-17 modulator 4
• 英文名: IL-17 modulator 4
• CAS号: 2446803-65-0
• 分子量: 474.60
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₇H₃₄N₆O₂
• 熔点: N/A
• 闪点: N/A

IL-17 modulator 4用途

IL-17调节剂4是IL-17调节剂1(HY-141535)的前药。IL-17调节剂1是一种口服活性、高效的IL-17调节剂[1]。

IL-17 modulator 4名称

• 英文名: IL-17 modulator 4

IL-17 modulator 4生物活性

• 描述: IL-17调节剂4是IL-17调节剂1(HY-141535)的前药。IL-17调节剂1是一种口服活性、高效的IL-17调节剂[1]。
• 相关类别:
  信号通路 >> 免疫及炎症 >> 白细胞介素相关
  研究领域 >> 炎症/免疫
• 参考文献:

  [1]. Kevin Neil Dack, et al. Amino-acid anilides as small molecule modulators of il-17. WO2020127685A1.

IL-17 modulator 4物理化学性质

• 分子式: C₂₇H₃₄N₆O₂
• 分子量: 474.60

IL-17 modulator 4靶点实验

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实验名称：Inhibition of Nav1.5 (unknown origin) at 10 uM 来源：ChEMBL 靶标：Sodium channel protein type 5 subunit alpha External Id：CHEMBL5136712

实验名称：Inhibition of Cav1.2 (unknown origin) at 10 uM 来源：ChEMBL 靶标：Voltage-dependent L-type calcium channel subunit alpha-1C External Id：CHEMBL5136713

实验名称：Clearance in Sprague-Dawley rat at 0.1 mg/kg, iv measured upto 24 hrs by LCMS/MS anal... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5136708

实验名称：Half life in Sprague-Dawley rat at 0.1 mg/kg, iv measured upto 24 hrs by LCMS/MS anal... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5136709

实验名称：Volume of distribution at steady state in Sprague-Dawley rat at 0.1 mg/kg, iv measure... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5136710

实验名称：Oral bioavailability in Sprague-Dawley rat at 2.6 mg/kg measured upto 24 hrs by LCMS/... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5136711

实验名称：Protein binding in human plasma assessed as unbound fraction at 1 uM by LCMS/MS analy... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5136704

实验名称：Metabolic stability in human hepatocytes assessed as apparent clearance at 0.5 uM mea... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5136705

实验名称：Apparent permeability of compound in human Caco2 cells from apical to basal 来源：ChEMBL 靶标：N/A External Id：CHEMBL5136706

实验名称：Apparent permeability of compound in human Caco2 cells from basal to apical 来源：ChEMBL 靶标：N/A External Id：CHEMBL5136707

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