Antiproliferative agent-5

• 常用名: Antiproliferative agent-5
• 英文名: Antiproliferative agent-5
• CAS号: 2459892-41-0
• 分子量: 597.49
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₈H₂₁BrN₈OS
• 熔点: N/A
• 闪点: N/A

Antiproliferative agent-5用途

抗增殖剂anti-5(化合物4o)能显著且不可逆地抑制胃癌细胞的增殖。抗增殖抗-5导致G2/M期阻滞,并诱导ROS积累和自噬激活。抗增殖剂anti-5可用于研究抗癌药物[1]。

Antiproliferative agent-5名称

• 英文名: Antiproliferative agent-5

Antiproliferative agent-5生物活性

• 描述: 抗增殖剂anti-5(化合物4o)能显著且不可逆地抑制胃癌细胞的增殖。抗增殖抗-5导致G2/M期阻滞,并诱导ROS积累和自噬激活。抗增殖剂anti-5可用于研究抗癌药物[1]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 蛋白酪氨酸激酶 >> ROS
  信号通路 >> 自噬 >> 自噬
• 靶点实验:

  ROS, Autophagy[1]

• 参考文献:

  [1]. Wang S, et al. Discovery of new [1,2,4] Triazolo[1,5-a]Pyrimidine derivatives that Kill gastric cancer cells via the mitochondria pathway. Eur J Med Chem. 2020;203:112630.

Antiproliferative agent-5物理化学性质

• 分子式: C₂₈H₂₁BrN₈OS
• 分子量: 597.49

Antiproliferative agent-5靶点实验

查看更多实验

实验名称：Induction of apoptosis in human MGC-803 cells assessed as decrease in accumulation of... 来源：ChEMBL 靶标：MGC-803 External Id：CHEMBL4708685

实验名称：Induction of apoptosis in human MGC-803 cells assessed as increase in accumulation of... 来源：ChEMBL 靶标：MGC-803 External Id：CHEMBL4708684

实验名称：Selectivity index, ratio of GI50 for human MGC803 to GI50 for human GES-1 cells 来源：ChEMBL 靶标：N/A External Id：CHEMBL4708686

实验名称：Induction of apoptosis in human MGC-803 cells assessed as increase in ROS production ... 来源：ChEMBL 靶标：MGC-803 External Id：CHEMBL4708677

实验名称：Induction of apoptosis in human MGC-803 cells assessed as increase in ROS production ... 来源：ChEMBL 靶标：MGC-803 External Id：CHEMBL4708676

实验名称：Antiproliferative activity in human MGC-803 cells assessed as inhibition of cell viab... 来源：ChEMBL 靶标：MGC-803 External Id：CHEMBL4708679

实验名称：Induction of apoptosis in human MGC-803 cells assessed as increase in ROS production ... 来源：ChEMBL 靶标：MGC-803 External Id：CHEMBL4708678

实验名称：Antiproliferative activity in human MGC-803 cells assessed as cell viability preincub... 来源：ChEMBL 靶标：MGC-803 External Id：CHEMBL4708681

实验名称：Antiproliferative activity in human MGC-803 cells assessed as inhibition of cell viab... 来源：ChEMBL 靶标：MGC-803 External Id：CHEMBL4708680

实验名称：Induction of apoptosis in human MGC-803 cells assessed as increase in accumulation of... 来源：ChEMBL 靶标：MGC-803 External Id：CHEMBL4708683

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