CDK1/Cyc B-IN-1

• 常用名: CDK1/Cyc B-IN-1
• 英文名: CDK1/Cyc B-IN-1
• CAS号: 2459916-56-2
• 分子量: 353.85
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₄H₁₂ClN₃O₂S₂
• 熔点: N/A
• 闪点: N/A

CDK1/Cyc B-IN-1用途

CDK1/Cyc B-IN-1(化合物5)是一种选择性CDK1/Cyc B复合物抑制剂,IC50为97 nM。CDK1/CycB-IN-1触发细胞凋亡和G2/M细胞周期阻滞。CDK1/Cyc B-IN-1对癌细胞系显示出广谱的细胞毒性作用【1】。

CDK1/Cyc B-IN-1名称

• 英文名: CDK1/Cyc B-IN-1

CDK1/Cyc B-IN-1生物活性

• 描述: CDK1/Cyc B-IN-1(化合物5)是一种选择性CDK1/Cyc B复合物抑制剂,IC50为97 nM。CDK1/CycB-IN-1触发细胞凋亡和G2/M细胞周期阻滞。CDK1/Cyc B-IN-1对癌细胞系显示出广谱的细胞毒性作用【1】。
• 相关类别:
  信号通路 >> 细胞凋亡 >> 细胞凋亡
  研究领域 >> 癌症
  信号通路 >> 细胞周期/DNA损伤 >> CDK
• 靶点实验:

  CDK1-Cyclin B:97 nM (IC50)

• 体外研究: CDK1/Cyc B-IN-1(化合物5)显示出细胞毒性活性,对HCT-116和WI-38的IC50值分别为5.33±0.69µM和21.69±1.04µM【1】。
• 参考文献:

  [1]. Mohamed SH, et al. An investigative study of antitumor properties of a novel thiazolo[4,5-d]pyrimidine small molecule revealing superior antitumor activity with CDK1 selectivity and potent pro-apoptotic properties. Bioorg Med Chem. 2020 Sep 1;28(17):115633.

CDK1/Cyc B-IN-1物理化学性质

• 分子式: C₁₄H₁₂ClN₃O₂S₂
• 分子量: 353.85

CDK1/Cyc B-IN-1靶点实验

查看更多实验

实验名称：Induction of apoptosis in human WI-38 cells assessed as necrotic cells at IC50 incuba... 来源：ChEMBL 靶标：WI-38 External Id：CHEMBL4727937

实验名称：Induction of apoptosis in human WI-38 cells assessed as early apoptotic cells at IC50... 来源：ChEMBL 靶标：WI-38 External Id：CHEMBL4727935

实验名称：Induction of apoptosis in human WI-38 cells assessed as late apoptotic cells at IC50 ... 来源：ChEMBL 靶标：WI-38 External Id：CHEMBL4727936

实验名称：Induction of apoptosis in human HCT116 cells assessed as up regulation of cytochrome ... 来源：ChEMBL 靶标：HCT-116 External Id：CHEMBL4727941

实验名称：Induction of apoptosis in human HCT116 cells assessed as up regulation of caspase-3 e... 来源：ChEMBL 靶标：HCT-116 External Id：CHEMBL4727942

实验名称：Induction of apoptosis in human HCT116 cells assessed as increase in p53 gene express... 来源：ChEMBL 靶标：HCT-116 External Id：CHEMBL4727939

实验名称：Induction of apoptosis in human HCT116 cells assessed as increase in Bax gene express... 来源：ChEMBL 靶标：HCT-116 External Id：CHEMBL4727940

实验名称：Cell cycle arrest in human WI-38 cells assessed as accumulation in G0/G1 phase at IC5... 来源：ChEMBL 靶标：WI-38 External Id：CHEMBL4727929

实验名称：Cell cycle arrest in human WI-38 cells assessed as accumulation in G2/M phase phase a... 来源：ChEMBL 靶标：WI-38 External Id：CHEMBL4727930

实验名称：Cell cycle arrest in human HCT-116 cells assessed as accumulation in S phase phase at... 来源：ChEMBL 靶标：HCT-116 External Id：CHEMBL4727927

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