PZ703b

• 常用名: PZ703b
• 英文名: PZ703b
• CAS号: 2471970-56-4
• 分子量: 1600.43
• 密度: N/A
• 沸点: N/A
• 分子式: C₈₀H₁₀₂ClF₃N₁₀O₁₁S₄
• 熔点: N/A
• 闪点: N/A

PZ703b用途

PZ703b是一种新型的BCL-XL蛋白降解剂,具有增强的BCL-2抑制作用。

PZ703b名称

• 英文名: PZ703b

PZ703b生物活性

• 描述: PZ703b是一种新型的BCL-XL蛋白降解剂,具有增强的BCL-2抑制作用。
• 相关类别:
  信号通路 >> 蛋白裂解靶向嵌合体 >> PROTAC
• 靶点实验:

  VHL

• 参考文献:

  [1]. Pal P, et al. Discovery of a Novel BCL-XL PROTAC Degrader with Enhanced BCL-2 Inhibition. J Med Chem. 2021 Oct 14;64(19):14230-14246.

PZ703b物理化学性质

• 分子式: C₈₀H₁₀₂ClF₃N₁₀O₁₁S₄
• 分子量: 1600.43
• InChIKey: CWIUDSZQDVZITQ-QFNMACOTSA-N
• SMILES: Cc1ncsc1-c1ccc(C(C)NC(=O)C2CC(O)CN2C(=O)C(NC(=O)CCCCCCCCC(=O)NCC2(C)CCC(c3ccc(Cl)cc3)=C(CN3CCN(c4ccc(C(=O)NS(=O)(=O)c5ccc(NC(CCN6CCOCC6)CSc6ccccc6)c(S(=O)(=O)C(F)(F)F)c5)cc4)CC3)C2)C(C)(C)C)cc1
• 储存条件: -20°C，干燥，密封

PZ703b安全信息

• 危害码 (欧洲): Xi

PZ703b靶点实验

查看更多实验

实验名称：Cytotoxicity against human RS4-11 cells assessed as reduction in cell viability measu... 来源：ChEMBL 靶标：RS4-11 External Id：CHEMBL5054275

实验名称：Protac activity at VHL/BCL-XL in human MOLT-4 cells assessed as decrease in BCL-XL pr... 来源：ChEMBL 靶标：von Hippel-Lindau disease tumor suppressor External Id：CHEMBL5054273

实验名称：Protac activity at VHL/BCL-XL in human RS4-11 cells assessed as decrease in BCL-XL pr... 来源：ChEMBL 靶标：von Hippel-Lindau disease tumor suppressor External Id：CHEMBL5054272

实验名称：Induction of apoptosis in human MOLT-4 cells assessed as decrease in cleaved caspase-... 来源：ChEMBL 靶标：MOLT-4 External Id：CHEMBL5054279

实验名称：Cytotoxicity against human MOLT-4 cells assessed as reduction in cell viability measu... 来源：ChEMBL 靶标：MOLT-4 External Id：CHEMBL5054276

实验名称：Protac activity at VHL/BCL-XL in human MOLT-4 cells assessed as induction of BCL-XL d... 来源：ChEMBL 靶标：von Hippel-Lindau disease tumor suppressor External Id：CHEMBL5054267

实验名称：Protac activity at VHL/BCL-XL in human MOLT-4 cells assessed as induction of BCL-XL d... 来源：ChEMBL 靶标：von Hippel-Lindau disease tumor suppressor External Id：CHEMBL5054266

实验名称：Protac activity at VHL/BCL-XL in human platelets assessed as decrease in BCL-XL prote... 来源：ChEMBL 靶标：von Hippel-Lindau disease tumor suppressor External Id：CHEMBL5054270

实验名称：Selectivity ratio of IC50 for human MOLT-4 cells to IC50 for platelets in human PRP 来源：ChEMBL 靶标：N/A External Id：CHEMBL5054269

实验名称：Protac activity at VHL/BCL-XL in human MOLT-4 cells assessed as induction of BCL-XL d... 来源：ChEMBL 靶标：von Hippel-Lindau disease tumor suppressor External Id：CHEMBL5054268

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