MPO-IN-5

更新时间：2025-08-27 19:20:40

MPO-IN-5用途

MPO-IN-5(化合物1)是一种有效的、不可逆的MPO(髓过氧化物酶)抑制剂。MPO-IN-5抑制MPO过氧化和hERG结合,IC50值分别为0.22和2.8μM。MPO-IN-5显示出快速的抑制动力学,酶失活率(kinact/Ki)为23000 M−1秒−1[1].

英文名	MPO-IN-5

描述	MPO-IN-5(化合物1)是一种有效的、不可逆的MPO(髓过氧化物酶)抑制剂。MPO-IN-5抑制MPO过氧化和hERG结合,IC50值分别为0.22和2.8μM。MPO-IN-5显示出快速的抑制动力学,酶失活率(kinact/Ki)为23000 M−1秒−1[1].
相关类别	研究领域 >> 炎症/免疫信号通路 >> 跨膜转运 >> 钾通道
靶点实验	IC50: 0.22 μM (MPO peroxidation), 2.8 μM (hERG binding), 30 μM (TPO)[1]
参考文献	[1]. Patnaik A, et al. Discovery of a novel indole pharmacophore for the irreversible inhibition of myeloperoxidase (MPO). Bioorg Med Chem. 2020 Jun 15;28(12):115548.

分子式	C₂₄H₂₄N₆O₂
分子量	428.49

实验名称：Irreversible inhibition of thyroid peroxidase (unknown origin) at 1000 fold dilution
来源：ChEMBL
靶标：Thyroid peroxidase
External Id：CHEMBL4624232

实验名称：Irreversible inhibition of myeloperoxidase (unknown origin) at 1000 fold dilution
来源：ChEMBL
靶标：Myeloperoxidase
External Id：CHEMBL4624231

实验名称：Irreversible inhibition of human myeloperoxidase assessed as residual activity using ...
来源：ChEMBL
靶标：Myeloperoxidase
External Id：CHEMBL4624234

实验名称：Irreversible inhibition of horseradish peroxidase at 1000 fold dilution
来源：ChEMBL
靶标：N/A
External Id：CHEMBL4624233

实验名称：Inhibition of myeloperoxidase (unknown origin)
来源：ChEMBL
靶标：Myeloperoxidase
External Id：CHEMBL4624235

实验名称：Inhibition of myeloperoxidase (unknown origin) assessed as partition ratio by Amplex ...
来源：ChEMBL
靶标：Myeloperoxidase
External Id：CHEMBL4624238

实验名称：Inhibition of myeloperoxidase (unknown origin) assessed as ratio of Kinact to Ki
来源：ChEMBL
靶标：Myeloperoxidase
External Id：CHEMBL4624237

实验名称：Solubility of the compound at pH 6.8
来源：ChEMBL
靶标：N/A
External Id：CHEMBL4624240

实验名称：Inhibition of thyroid peroxidase (unknown origin)
来源：ChEMBL
靶标：Thyroid peroxidase
External Id：CHEMBL4624239

实验名称：Inhibition of CYP3A4 (unknown origin)
来源：ChEMBL
靶标：Cytochrome P450 3A4
External Id：CHEMBL4624242

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