FLT3/ITD-IN-3

• 常用名: FLT3/ITD-IN-3
• 英文名: FLT3/ITD-IN-3
• CAS号: 2489446-47-9
• 分子量: 455.94
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₂H₂₆ClN₇O₂
• 熔点: N/A
• 闪点: N/A

FLT3/ITD-IN-3用途

FLT3/ITD-IN-3(化合物19)是一种有效的FLT3内部串联重复(FLT3-ITD)抑制剂,对FLT3D835Y、FLT3和FLT3-ITD的IC50值分别为0.3、0.4和0.9 nM。FLT3/ITD-IN-3可有效抑制FLT3的磷酸化,并对急性髓系白血病细胞系具有良好的抗增殖活性[1]。

FLT3/ITD-IN-3名称

• 英文名: FLT3/ITD-IN-3

FLT3/ITD-IN-3生物活性

• 描述: FLT3/ITD-IN-3(化合物19)是一种有效的FLT3内部串联重复(FLT3-ITD)抑制剂,对FLT3D835Y、FLT3和FLT3-ITD的IC50值分别为0.3、0.4和0.9 nM。FLT3/ITD-IN-3可有效抑制FLT3的磷酸化,并对急性髓系白血病细胞系具有良好的抗增殖活性[1]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 蛋白酪氨酸激酶 >> FLT3
• 靶点实验:

  IC50: 0.3 nM (FLT3D835Y), 0.4 nM (FLT3), 0.9 nM (FLT3-ITD)[1]

• 参考文献:

  [1]. Chen Y, et al. Discovery and structure - activity relationship exploration of pyrazolo[1,5-a]pyrimidine derivatives as potent FLT3-ITD inhibitors. Bioorg Med Chem. 2021 Oct 15;48:116422.

FLT3/ITD-IN-3物理化学性质

• 分子式: C₂₂H₂₆ClN₇O₂
• 分子量: 455.94

FLT3/ITD-IN-3靶点实验

查看更多实验

实验名称：Inhibition of RET (unknown origin) at 0.1 uM using Poly (Glu,Tyr) 4:1 as substrate in... 来源：ChEMBL 靶标：Proto-oncogene tyrosine-protein kinase receptor Ret External Id：CHEMBL5054531

实验名称：Inhibition of PDGFRbeta (unknown origin) at 0.1 uM using Poly (Glu,Tyr) 4:1 as substr... 来源：ChEMBL 靶标：Platelet-derived growth factor receptor beta External Id：CHEMBL5054530

实验名称：Inhibition of PDGFRalpha (unknown origin) at 0.1 uM using Poly (Glu,Tyr) 4:1 as subst... 来源：ChEMBL 靶标：Platelet-derived growth factor receptor alpha External Id：CHEMBL5054529

实验名称：Inhibition of VEGFR-3 (unknown origin) at 0.1 uM using Poly (Glu,Tyr) 4:1 as substrat... 来源：ChEMBL 靶标：Vascular endothelial growth factor receptor 3 External Id：CHEMBL5054528

实验名称：Inhibition of ERBB4(unknown origin) at 0.1 uM using Poly (Glu,Tyr) 4:1 as substrate i... 来源：ChEMBL 靶标：Receptor tyrosine-protein kinase erbB-4 External Id：CHEMBL5054535

实验名称：Inhibition of ERBB2 (unknown origin) at 0.1 uM using Poly (Glu,Tyr) 4:1 as substrate ... 来源：ChEMBL 靶标：Receptor tyrosine-protein kinase erbB-2 External Id：CHEMBL5054534

实验名称：Inhibition of EGFR (unknown origin) at 0.1 uM using Poly (Glu,Tyr) 4:1 as substrate i... 来源：ChEMBL 靶标：Epidermal growth factor receptor External Id：CHEMBL5054533

实验名称：Inhibition of c-Kit (unknown origin) at 0.1 uM using Poly (Glu,Tyr) 4:1 as substrate ... 来源：ChEMBL 靶标：Mast/stem cell growth factor receptor Kit External Id：CHEMBL5054532

实验名称：Antiproliferative activity against human MOLM-13 cells assessed as reduction in cell ... 来源：ChEMBL 靶标：MOLM-13 External Id：CHEMBL5054521

实验名称：Inhibition of FLT3-ITD mutant (unknown origin) using Poly (Glu,Tyr) 4:1 as substrate ... 来源：ChEMBL 靶标：Receptor-type tyrosine-protein kinase FLT3 External Id：CHEMBL5054520

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