sEH/AChE-IN-3

• 常用名: sEH/AChE-IN-3
• 英文名: sEH/AChE-IN-3
• CAS号: 2490589-11-0
• 分子量: 670.16
• 密度: N/A
• 沸点: N/A
• 分子式: C₃₅H₃₉ClF₃N₅O₃
• 熔点: N/A
• 闪点: N/A

sEH/AChE-IN-3用途

sEH/AChE-IN-3(化合物(−)-15) 是sEH(可溶性环氧化物水解酶)和AChE(乙酰胆碱酯酶)的一种有效的BBB穿透双重抑制剂,IC50值分别为0.4 nM(hsEH)、1.94 nM(hAChE)、615 nM(hBChE,人类丁酰胆碱酯酶)、4.3 nM(msEH)和2.61 nM(mAChE)[1]。

sEH/AChE-IN-3名称

• 英文名: sEH/AChE-IN-3

sEH/AChE-IN-3生物活性

• 描述: sEH/AChE-IN-3(化合物(−)-15) 是sEH(可溶性环氧化物水解酶)和AChE(乙酰胆碱酯酶)的一种有效的BBB穿透双重抑制剂,IC50值分别为0.4 nM(hsEH)、1.94 nM(hAChE)、615 nM(hBChE,人类丁酰胆碱酯酶)、4.3 nM(msEH)和2.61 nM(mAChE)[1]。
• 相关类别:
  研究领域 >> 癌症
  研究领域 >> 神经疾病
  信号通路 >> 神经信号通路 >> 疼痛
• 靶点实验:

  IC50: 0.4 nM (hsEH), 1.94 ± 0.67 nM (hAChE), 615 ± 34 nM (hBChE), 4.3 nM (msEH), 2.61 ± 0.16 nM (mAChE)[1]

• 参考文献:

  [1]. Codony S, et al. Discovery and In Vivo Proof of Concept of a Highly Potent Dual Inhibitor of Soluble Epoxide Hydrolase and Acetylcholinesterase for the Treatment of Alzheimer's Disease. J Med Chem. 2022 Mar 24;65(6):4909-4925.

sEH/AChE-IN-3物理化学性质

• 分子式: C₃₅H₃₉ClF₃N₅O₃
• 分子量: 670.16
• InChIKey: VPHLBLQNXMWQOL-XZOQPEGZSA-N
• SMILES: CC1=CC2Cc3nc4cc(Cl)ccc4c(NCCCCC(=O)N4CCC(NC(=O)Nc5ccc(OC(F)(F)F)cc5)CC4)c3C(C1)C2

sEH/AChE-IN-3靶点实验

查看更多实验

实验名称：Metabolic stability in mouse liver microsomes assessed as half life measured upto 60 ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5161357

实验名称：Metabolic stability in mouse liver microsomes assessed as parent compound remaining m... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5161356

实验名称：Metabolic stability in rat liver microsomes assessed as parent compound remaining mea... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5161359

实验名称：Metabolic stability in mouse liver microsomes assessed as intrinsic clearance measure... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5161358

实验名称：Metabolic stability in human liver microsomes assessed as parent compound remaining m... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5161353

实验名称：Metabolic stability in human liver microsomes assessed as intrinsic clearance measure... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5161355

实验名称：Metabolic stability in human liver microsomes assessed as half life measured upto 60 ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5161354

实验名称：Permeability of the compound by PAMPA-BBB assay 来源：ChEMBL 靶标：N/A External Id：CHEMBL5161350

实验名称：Metabolic stability in rat liver microsomes assessed as intrinsic clearance measured ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5161361

实验名称：Metabolic stability in rat liver microsomes assessed as half life measured upto 60 mi... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5161360

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