LDHA/PDKs-IN-1

• 常用名: LDHA/PDKs-IN-1
• 英文名: LDHA/PDKs-IN-1
• CAS号: 2490699-40-4
• 分子量: 360.38
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₉H₂₁FN₂O₄
• 熔点: N/A
• 闪点: N/A

LDHA/PDKs-IN-1用途

LDHA/PDKs-IN-1(化合物20e)是PDKs和LDHA的有效双重抑制剂,其IC50s分别为0.8和0.15μM。LDHA/PDKs-IN-1降低A549细胞增殖,EC50为13.2μM,减少乳酸形成,增加耗氧量。LDHA/PDKs-IN-1在癌症疾病研究中具有潜在的应用前景[1]。

LDHA/PDKs-IN-1名称

• 英文名: LDHA/PDKs-IN-1

LDHA/PDKs-IN-1生物活性

• 描述: LDHA/PDKs-IN-1(化合物20e)是PDKs和LDHA的有效双重抑制剂,其IC50s分别为0.8和0.15μM。LDHA/PDKs-IN-1降低A549细胞增殖,EC50为13.2μM,减少乳酸形成,增加耗氧量。LDHA/PDKs-IN-1在癌症疾病研究中具有潜在的应用前景[1]。
• 相关类别:
  信号通路 >> PI3K/Akt/mTOR 信号通路 >> PDK-1
  研究领域 >> 癌症
• 参考文献:

  [1]. Xiang S, et al. Development of dual inhibitors targeting pyruvate dehydrogenase kinases and human lactate dehydrogenase A: High-throughput virtual screening, synthesis and biological validation. Eur J Med Chem. 2020;203:112579.

LDHA/PDKs-IN-1物理化学性质

• 分子式: C₁₉H₂₁FN₂O₄
• 分子量: 360.38
• InChIKey: AHYWOCBRZPCRAD-UHFFFAOYSA-N
• SMILES: Cc1occc(=O)c1OCCN1CCN(C(=O)c2ccc(F)cc2)CC1

LDHA/PDKs-IN-1靶点实验

查看更多实验

实验名称：Inhibition of pig PDK assessed as catalytic activity measured after 30 mins by microp... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4708691

实验名称：Inhibition of LDHA (unknown origin) in presence of NADH and sodium pyruvate measured ... 来源：ChEMBL 靶标：L-lactate dehydrogenase A chain External Id：CHEMBL4708690

实验名称：Metabolic modulatory effect in human A549 cells assessed as decrease in lactate forma... 来源：ChEMBL 靶标：A549 External Id：CHEMBL4708693

实验名称：Anticancer activity against human A549 assessed as cell growth inhibition measured af... 来源：ChEMBL 靶标：A549 External Id：CHEMBL4708692

实验名称：Metabolic modulatory effect in human A549 cells assessed as increase in oxygen consum... 来源：ChEMBL 靶标：A549 External Id：CHEMBL4708694

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