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乙酰螺旋霉素

更新时间:2024-01-02 17:57:47

乙酰螺旋霉素结构式
乙酰螺旋霉素结构式
品牌特惠专场
常用名 乙酰螺旋霉素 英文名 Acetylspiramycin
CAS号 24916-51-6 分子量 885.089
密度 1.2±0.1 g/cm3 沸点 916.7±65.0 °C at 760 mmHg
分子式 C45H76N2O15 熔点 130-133ºC
MSDS N/A 闪点 508.2±34.3 °C

 乙酰螺旋霉素用途


Acetylspiramycin 是一种大环内酯类抗生素。

 乙酰螺旋霉素作用


抗菌谱近似红霉素,对葡萄球菌、化脓性链球菌、肺炎链球菌、脑膜炎球菌、淋球菌、白喉杆菌、支原体、梅毒螺旋体等有抗菌作用。口服100mg或200mg,于2小时血药浓度达峰,分别为0.8μg/ml和1μg/ml。体内分布以肺脏、肝脏较多,胆汁中浓度可达血清浓度的7-10倍,尿液中排泄甚少。本品不能透过正常人的血脑障。

 乙酰螺旋霉素名称

中文名 乙酰螺旋霉素
英文名 spiramycin II
英文别名 更多

 乙酰螺旋霉素生物活性

描述 Acetylspiramycin 是一种大环内酯类抗生素。
相关类别
靶点

Bacterial[1]

参考文献

[1]. Huang MZ, et al. Therapeutic effects of acetylspiramycin and garlicin on cryptosporidiosis among drug users. Int J Parasitol Drugs Drug Resist. 2015 Dec;5(3):185-90.

 乙酰螺旋霉素物理化学性质

密度 1.2±0.1 g/cm3
沸点 916.7±65.0 °C at 760 mmHg
熔点 130-133ºC
分子式 C45H76N2O15
分子量 885.089
闪点 508.2±34.3 °C
精确质量 884.524597
PSA 201.45000
LogP 3.60
外观性状 白色粉末
蒸汽压 0.0±0.6 mmHg at 25°C
折射率 1.543
储存条件 -20℃

 乙酰螺旋霉素毒性和生态

 乙酰螺旋霉素英文别名

Acetylspiramycin
(4R,5S,6S,7R,9R,10R,11E,13E,16R)-6-{[(2S,3R,4R,5S,6R)-5-{[(2S,4R,5S,6S)-4,5-Dihydroxy-4,6-dimethyltetrahydro-2H-pyran-2-yl]oxy}-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy}-10-{[(2R,5S,6S)-5-(dimethylamino)-6-methyltetrahydro-2H-pyran-2-yl]oxy}-5-methoxy-9,16-dimethyl-2-oxo-7-(2-oxoethyl)oxacyclohexadeca-11,13-dien-4-yl acetate
(4R,5S,6S,7R,9R,10R,11E,13E,16R)-6-{[(2S,3R,4R,5S,6R)-5-{[(2S,4R,5S,6S)-4,5-Dihydroxy-4,6-dimethyltetrahydro-2H-pyran-2-yl]oxy}-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy}-10-{[(2R,5S,6R)-5-(dimethylamino)-6-methyltetrahydro-2H-pyran-2-yl]oxy}-5-methoxy-9,16-dimethyl-2-oxo-7-(2-oxoethyl)oxacyclohexadeca-11,13-dien-4-yl acetate (non-preferred name)
(4R,5S,6S,7R,9R,10R,11E,13E,16R)-6-{[(2S,3R,4R,5S,6R)-5-{[(2S,4R,5S,6S)-4,5-Dihydroxy-4,6-dimethyltetrahydro-2H-pyran-2-yl]oxy}-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy}-10-{[(2R,5S,6R)-5-(dimethylamino)-6-methyltetrahydro-2H-pyran-2-yl]oxy}-5-methoxy-9,16-dimethyl-2-oxo-7-(2-oxoethyl)oxacyclohexadeca-11,13-dien-4-yl acetate
Acetyl Spiramycin
(4R,5S,6S,7R,9R,10R,11E,13E,16R)-6-{[(2S,3R,4R,5S,6R)-5-{[(2S,4R,5S,6S)-4,5-Dihydroxy-4,6-dimethyltetrahydro-2H-pyran-2-yl]oxy}-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy}-10-{[(2R,5S,6S)-5-(dimethylamino)-6-methyltetrahydro-2H-pyran-2-yl]oxy}-5-methoxy-9,16-dimethyl-2-oxo-7-(2-oxoethyl)oxacyclohexadeca-11,13-dien-4-yl acetate (non-preferred name)
spiramycin II
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