乙酰螺旋霉素

• 常用名: 乙酰螺旋霉素
• 英文名: Acetylspiramycin
• CAS号: 24916-51-6
• 分子量: 885.089
• 密度: 1.2±0.1 g/cm3
• 沸点: 916.7±65.0 °C at 760 mmHg
• 分子式: C₄₅H₇₆N₂O₁₅
• 熔点: 130-133ºC
• 闪点: 508.2±34.3 °C

乙酰螺旋霉素用途

Acetylspiramycin 是一种大环内酯类抗生素。

乙酰螺旋霉素作用

抗菌谱近似红霉素，对葡萄球菌、化脓性链球菌、肺炎链球菌、脑膜炎球菌、淋球菌、白喉杆菌、支原体、梅毒螺旋体等有抗菌作用。口服100mg或200mg，于2小时血药浓度达峰，分别为0.8μg/ml和1μg/ml。体内分布以肺脏、肝脏较多，胆汁中浓度可达血清浓度的7-10倍，尿液中排泄甚少。本品不能透过正常人的血脑障。

乙酰螺旋霉素名称

• 中文名: 乙酰螺旋霉素
• 英文名: spiramycin II

乙酰螺旋霉素生物活性

• 描述: Acetylspiramycin 是一种大环内酯类抗生素。
• 相关类别:
  信号通路 >> 抗感染 >> 细菌
  研究领域 >> 感染
• 靶点实验:

  Bacterial[1]

• 参考文献:

  [1]. Huang MZ, et al. Therapeutic effects of acetylspiramycin and garlicin on cryptosporidiosis among drug users. Int J Parasitol Drugs Drug Resist. 2015 Dec;5(3):185-90.

乙酰螺旋霉素物理化学性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 916.7±65.0 °C at 760 mmHg
• 熔点: 130-133ºC
• 分子式: C₄₅H₇₆N₂O₁₅
• 分子量: 885.089
• 闪点: 508.2±34.3 °C
• 精确质量: 884.524597
• PSA: 201.45000
• LogP: 3.60
• InChIKey: ZPCCSZFPOXBNDL-WKHLYWTKSA-N
• SMILES: COC1C(OC(C)=O)CC(=O)OC(C)CC=CC=CC(OC2CCC(N(C)C)C(C)O2)C(C)CC(CC=O)C1OC1OC(C)C(OC2CC(C)(O)C(O)C(C)O2)C(N(C)C)C1O
• 外观性状: 白色粉末
• 蒸汽压: 0.0±0.6 mmHg at 25°C
• 折射率: 1.543
• 储存条件: -20℃

乙酰螺旋霉素毒性和生态

乙酰螺旋霉素靶点实验

查看更多实验

实验名称：AlphaScreen-based biochemical high throughput primary assay to identify inhibitors of... 来源：The Scripps Research Institute Molecular Screening Center 靶标：N/A External Id：ULK1_INH_LUMI_1536_1X%INH PRUN

实验名称：Anti-tachyzoite activity against Toxoplasma gondii RH infected in kunming mouse model... 来源：ChEMBL 靶标：Toxoplasma gondii External Id：CHEMBL5135452

实验名称：Anti-tachyzoite activity against Toxoplasma gondii RH infected in Kunming mouse model... 来源：ChEMBL 靶标：Toxoplasma gondii External Id：CHEMBL5135439

实验名称：Anti-tachyzoite activity against Toxoplasma gondii RH infected in kunming mouse model... 来源：ChEMBL 靶标：Toxoplasma gondii External Id：CHEMBL5135449

实验名称：Anti-tachyzoite activity against Toxoplasma gondii RH infected in kunming mouse model... 来源：ChEMBL 靶标：Toxoplasma gondii External Id：CHEMBL5135450

实验名称：Anti-tachyzoite activity against Toxoplasma gondii RH infected in kunming mouse model... 来源：ChEMBL 靶标：Toxoplasma gondii External Id：CHEMBL5135451

实验名称：Cell-based high throughput primary assay to identify activators of GPR151 来源：The Scripps Research Institute Molecular Screening Center 靶标：RecName: Full=G-protein coupled receptor 151; AltName: Full=G-protein coupled receptor PGR7; AltName: Full=GPCR-2037; AltName: Full=Galanin receptor 4; AltName: Full=Galanin-receptor-like protein; Short=GalRL External Id：GPR151_PHUNTER_AG_LUMI_1536_1X%ACT

实验名称：AlphaScreen-based biochemical high throughput primary assay to identify activators of... 来源：The Scripps Research Institute Molecular Screening Center 靶标：N/A External Id：FBW7_ACT_ALPHA_1536_1X%ACT PRUN

实验名称：AlphaScreen-based biochemical high throughput primary assay to identify inhibitors of... 来源：The Scripps Research Institute Molecular Screening Center External Id：MITF_INH_Alpha_1536_1X%INH PRUN

实验名称：Inhibition of cell viability relative to arbidol control (inhibition index > 1 indica... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4303819

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乙酰螺旋霉素英文别名

• Acetylspiramycin
• (4R,5S,6S,7R,9R,10R,11E,13E,16R)-6-{[(2S,3R,4R,5S,6R)-5-{[(2S,4R,5S,6S)-4,5-Dihydroxy-4,6-dimethyltetrahydro-2H-pyran-2-yl]oxy}-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy}-10-{[(2R,5S,6S)-5-(dimethylamino)-6-methyltetrahydro-2H-pyran-2-yl]oxy}-5-methoxy-9,16-dimethyl-2-oxo-7-(2-oxoethyl)oxacyclohexadeca-11,13-dien-4-yl acetate
• (4R,5S,6S,7R,9R,10R,11E,13E,16R)-6-{[(2S,3R,4R,5S,6R)-5-{[(2S,4R,5S,6S)-4,5-Dihydroxy-4,6-dimethyltetrahydro-2H-pyran-2-yl]oxy}-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy}-10-{[(2R,5S,6R)-5-(dimethylamino)-6-methyltetrahydro-2H-pyran-2-yl]oxy}-5-methoxy-9,16-dimethyl-2-oxo-7-(2-oxoethyl)oxacyclohexadeca-11,13-dien-4-yl acetate (non-preferred name)
• (4R,5S,6S,7R,9R,10R,11E,13E,16R)-6-{[(2S,3R,4R,5S,6R)-5-{[(2S,4R,5S,6S)-4,5-Dihydroxy-4,6-dimethyltetrahydro-2H-pyran-2-yl]oxy}-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy}-10-{[(2R,5S,6R)-5-(dimethylamino)-6-methyltetrahydro-2H-pyran-2-yl]oxy}-5-methoxy-9,16-dimethyl-2-oxo-7-(2-oxoethyl)oxacyclohexadeca-11,13-dien-4-yl acetate
• Acetyl Spiramycin
• (4R,5S,6S,7R,9R,10R,11E,13E,16R)-6-{[(2S,3R,4R,5S,6R)-5-{[(2S,4R,5S,6S)-4,5-Dihydroxy-4,6-dimethyltetrahydro-2H-pyran-2-yl]oxy}-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy}-10-{[(2R,5S,6S)-5-(dimethylamino)-6-methyltetrahydro-2H-pyran-2-yl]oxy}-5-methoxy-9,16-dimethyl-2-oxo-7-(2-oxoethyl)oxacyclohexadeca-11,13-dien-4-yl acetate (non-preferred name)
• spiramycin II